Current status of flavivirus vaccines - PubMed (original) (raw)

Review

Current status of flavivirus vaccines

A D Barrett. Ann N Y Acad Sci. 2001 Dec.

Abstract

Although there are approximately 68 flaviviruses recognized, vaccines have been developed to control very few human flavivirus diseases. Licensed live attenuated vaccines have been developed for yellow fever (strain 17D) and Japanese encephalitis (strain SA14-14-2) viruses, and inactivated vaccines have been developed for Japanese encephalitis and tick-borne encephalitis viruses. The yellow fever live attenuated 17D vaccine is one of the most efficacious and safe vaccines developed to date and has been used to immunize more than 300 million people. A number of experimental vaccines are being developed, most notably for dengue. Candidate tetravalent live attenuated dengue vaccines are undergoing clinical trials. Other vaccines are being developed using reverse genetics, DNA vaccines, and recombinant immunogens. In addition, the yellow fever 17D vaccine has been used as a backbone to generate chimeric viruses containing the premembrane and envelope protein genes from other flaviviruses. The "Chimerivax" platform has been used to construct chimeric Japanese encephalitis and dengue viruses that are in different phases of development. Similar strategies are being used by other laboratories.

PubMed Disclaimer

Similar articles

• Flaviviruses and flavivirus vaccines.
  Heinz FX, Stiasny K. Heinz FX, et al. Vaccine. 2012 Jun 19;30(29):4301-6. doi: 10.1016/j.vaccine.2011.09.114. Vaccine. 2012. PMID: 22682286 Review.
• Chimeric flaviviruses: novel vaccines against dengue fever, tick-borne encephalitis, and Japanese encephalitis.
  Lai CJ, Monath TP. Lai CJ, et al. Adv Virus Res. 2003;61:469-509. doi: 10.1016/s0065-3527(03)61013-4. Adv Virus Res. 2003. PMID: 14714441 Review.
• A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available.
  Ishikawa T, Yamanaka A, Konishi E. Ishikawa T, et al. Vaccine. 2014 Mar 10;32(12):1326-37. doi: 10.1016/j.vaccine.2014.01.040. Epub 2014 Jan 29. Vaccine. 2014. PMID: 24486372 Review.
• New developments in flavivirus vaccines with special attention to yellow fever.
  Pugachev KV, Guirakhoo F, Monath TP. Pugachev KV, et al. Curr Opin Infect Dis. 2005 Oct;18(5):387-94. doi: 10.1097/01.qco.0000178823.28585.ad. Curr Opin Infect Dis. 2005. PMID: 16148524 Review.
• Traditional and novel approaches to flavivirus vaccines.
  Pugachev KV, Guirakhoo F, Trent DW, Monath TP. Pugachev KV, et al. Int J Parasitol. 2003 May;33(5-6):567-82. doi: 10.1016/s0020-7519(03)00063-8. Int J Parasitol. 2003. PMID: 12782056 Review.

Cited by

• Vaccines for preventing Japanese encephalitis.
  Schiøler KL, Samuel M, Wai KL. Schiøler KL, et al. Cochrane Database Syst Rev. 2007 Jul 18;2007(3):CD004263. doi: 10.1002/14651858.CD004263.pub2. Cochrane Database Syst Rev. 2007. PMID: 17636750 Free PMC article. Review.
• Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts.
  Kanagaraj AP, Verma D, Daniell H. Kanagaraj AP, et al. Plant Mol Biol. 2011 Jul;76(3-5):323-33. doi: 10.1007/s11103-011-9766-0. Epub 2011 Mar 24. Plant Mol Biol. 2011. PMID: 21431782 Free PMC article.
• Tick-borne encephalopathies : epidemiology, diagnosis, treatment and prevention.
  Günther G, Haglund M. Günther G, et al. CNS Drugs. 2005;19(12):1009-32. doi: 10.2165/00023210-200519120-00004. CNS Drugs. 2005. PMID: 16332143 Review.
• Recent Advancements in Mosquito-Borne Flavivirus Vaccine Development.
  Wu B, Qi Z, Qian X. Wu B, et al. Viruses. 2023 Mar 23;15(4):813. doi: 10.3390/v15040813. Viruses. 2023. PMID: 37112794 Free PMC article. Review.
• Conserved MHC class I-presented dengue virus epitopes identified by immunoproteomics analysis are targets for cross-serotype reactive T-cell response.
  Testa JS, Shetty V, Sinnathamby G, Nickens Z, Hafner J, Kamal S, Zhang X, Jett M, Philip R. Testa JS, et al. J Infect Dis. 2012 Feb 15;205(4):647-55. doi: 10.1093/infdis/jir814. Epub 2012 Jan 13. J Infect Dis. 2012. PMID: 22246683 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database