Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma - PubMed (original) (raw)
. 2002 Feb 25;176(2):149-58.
doi: 10.1016/s0304-3835(01)00736-4.
Yasuhiro Yumoto, Kazuhiro Nouso, Harushige Nakatsukasa, Toru Onishi, Tatsuya Fujikawa, Mayumi Taniyama, Shinichiro Nakamura, Masayuki Uemura, Yoshitaka Takuma, Eiichiro Yumoto, Toshihiro Higashi, Takao Tsuji
Affiliations
- PMID: 11804742
- DOI: 10.1016/s0304-3835(01)00736-4
Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma
Tadashi Hanafusa et al. Cancer Lett. 2002.
Abstract
Insulin-like growth factor binding protein-3 (IGFBP-3) is postulated to be a mediator of growth suppression signals. Reduced expression of the IGFBP-3 was observed in nine out of 12 human hepatocellular carcinomas (HCC) (75%). Promoter hypermethylation of the IGFBP-3 was detected in four out of 12 HCCs (33%) although mutations were not identified. The expression of IGFBP-3 was restored by the demethylating agent 5-aza-2'-deoxycytidine in HCC cell line with promoter hypermethylation (HepG2). As IGFBP-3 functions like a tumor suppressor gene, it may be used as a therapeutic target for HCC.
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