The origin of the eukaryotic cell: a genomic investigation - PubMed (original) (raw)
The origin of the eukaryotic cell: a genomic investigation
Hyman Hartman et al. Proc Natl Acad Sci U S A. 2002.
Erratum in
- Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4752
Abstract
We have collected a set of 347 proteins that are found in eukaryotic cells but have no significant homology to proteins in Archaea and Bacteria. We call these proteins eukaryotic signature proteins (ESPs). The dominant hypothesis for the formation of the eukaryotic cell is that it is a fusion of an archaeon with a bacterium. If this hypothesis is accepted then the three cellular domains, Eukarya, Archaea, and Bacteria, would collapse into two cellular domains. We have used the existence of this set of ESPs to test this hypothesis. The evidence of the ESPs implicates a third cell (chronocyte) in the formation of the eukaryotic cell. The chronocyte had a cytoskeleton that enabled it to engulf prokaryotic cells and a complex internal membrane system where lipids and proteins were synthesized. It also had a complex internal signaling system involving calcium ions, calmodulin, inositol phosphates, ubiquitin, cyclin, and GTP-binding proteins. The nucleus was formed when a number of archaea and bacteria were engulfed by a chronocyte. This formation of the nucleus would restore the three cellular domains as the Chronocyte was not a cell that belonged to the Archaea or to the Bacteria.
Similar articles
- What does the microsporidian E. cuniculi tell us about the origin of the eukaryotic cell?
Fedorov A, Hartman H. Fedorov A, et al. J Mol Evol. 2004 Nov;59(5):695-702. doi: 10.1007/s00239-003-0085-1. J Mol Evol. 2004. PMID: 15693625 - [Homologous protein domains in superkingdoms Archaea, Bacteria, and Eukaryota and the problem of the origin of eukaryotes].
Markov AV, Kulikov AM. Markov AV, et al. Izv Akad Nauk Ser Biol. 2005 Jul-Aug;(4):389-400. Izv Akad Nauk Ser Biol. 2005. PMID: 16212260 Review. Russian. - From pre-cells to Eukarya--a tale of two lipids.
Wächtershäuser G. Wächtershäuser G. Mol Microbiol. 2003 Jan;47(1):13-22. doi: 10.1046/j.1365-2958.2003.03267.x. Mol Microbiol. 2003. PMID: 12492850 - Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell-walled Eukarya.
Kloda A, Martinac B. Kloda A, et al. Archaea. 2002 Mar;1(1):35-44. doi: 10.1155/2002/419261. Archaea. 2002. PMID: 15803657 Free PMC article. - The prokaryotic origin and evolution of eukaryotic chemosignaling systems.
Pertseva MN, Shpakov AO. Pertseva MN, et al. Neurosci Behav Physiol. 2009 Oct;39(8):793-804. doi: 10.1007/s11055-009-9190-y. Epub 2009 Sep 23. Neurosci Behav Physiol. 2009. PMID: 19779832 Review.
Cited by
- Diversity, origin, and evolution of the ESCRT systems.
Makarova KS, Tobiasson V, Wolf YI, Lu Z, Liu Y, Zhang S, Krupovic M, Li M, Koonin EV. Makarova KS, et al. mBio. 2024 Mar 13;15(3):e0033524. doi: 10.1128/mbio.00335-24. Epub 2024 Feb 21. mBio. 2024. PMID: 38380930 Free PMC article. - Progress and challenges of graphene and its congeners for biomedical applications.
Kaur H, Garg R, Singh S, Jana A, Bathula C, Kim HS, Kumbar SG, Mittal M. Kaur H, et al. J Mol Liq. 2022 Dec 15;368(A):120703. doi: 10.1016/j.molliq.2022.120703. Epub 2022 Nov 1. J Mol Liq. 2022. PMID: 38130892 Free PMC article. - Editorial: Algal symbiotic relationships in freshwater and marine environments.
Tirichine L, Piganeau G. Tirichine L, et al. Front Plant Sci. 2023 Feb 20;14:1155759. doi: 10.3389/fpls.2023.1155759. eCollection 2023. Front Plant Sci. 2023. PMID: 36890883 Free PMC article. No abstract available. - Cyanobacterial membrane dynamics in the light of eukaryotic principles.
Siebenaller C, Schneider D. Siebenaller C, et al. Biosci Rep. 2023 Feb 27;43(2):BSR20221269. doi: 10.1042/BSR20221269. Biosci Rep. 2023. PMID: 36602300 Free PMC article. - Sex in protists: A new perspective on the reproduction mechanisms of trypanosomatids.
Silva VSD, Machado CR. Silva VSD, et al. Genet Mol Biol. 2022 Oct 10;45(3):e20220065. doi: 10.1590/1678-4685-GMB-2022-0065. eCollection 2022. Genet Mol Biol. 2022. PMID: 36218381 Free PMC article.
References
- Horiike T, Hamada K, Kanaya S, Shinozawa T. Nat Cell Biol. 2001;3:210–214. - PubMed
- Doolittle W F, Logsdon J M., Jr Curr Biol. 1998;8:R209–211. - PubMed
- Gillin F D, Reiner D S, McCaffery J M. Annu Rev Microbiol. 1996;50:679–705. - PubMed
- Mereschowsky C. Biol Zentralbl. 1910;30:278–367.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous