Resistin, central obesity, and type 2 diabetes - PubMed (original) (raw)
Resistin, central obesity, and type 2 diabetes
C L McTernan et al. Lancet. 2002.
Abstract
Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
Similar articles
- Increased resistin gene and protein expression in human abdominal adipose tissue.
McTernan PG, McTernan CL, Chetty R, Jenner K, Fisher FM, Lauer MN, Crocker J, Barnett AH, Kumar S. McTernan PG, et al. J Clin Endocrinol Metab. 2002 May;87(5):2407. doi: 10.1210/jcem.87.5.8627. J Clin Endocrinol Metab. 2002. PMID: 11994397 - [Resistine--a new hormone secreted by adipose tissue (adipose tissue in insulin resistance)].
Kochan Z, Karbowska J. Kochan Z, et al. Przegl Lek. 2003;60(1):40-2. Przegl Lek. 2003. PMID: 12884646 Review. Polish. - Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss.
Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R. Milan G, et al. Obes Res. 2002 Nov;10(11):1095-103. doi: 10.1038/oby.2002.149. Obes Res. 2002. PMID: 12429872 - Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle.
Nagaev I, Smith U. Nagaev I, et al. Biochem Biophys Res Commun. 2001 Jul 13;285(2):561-4. doi: 10.1006/bbrc.2001.5173. Biochem Biophys Res Commun. 2001. PMID: 11444881 - Adiponectin and resistin--new hormones of white adipose tissue.
Bełtowski J. Bełtowski J. Med Sci Monit. 2003 Feb;9(2):RA55-61. Med Sci Monit. 2003. PMID: 12601307 Review.
Cited by
- The expression of resistin in adipose tissues of patients with polycystic ovary syndrome and insulin resistance.
Chu Y, Cui Q, Feng G, Song Z, Jiang X. Chu Y, et al. J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):642-5. doi: 10.1007/s11596-009-0521-6. Epub 2009 Oct 11. J Huazhong Univ Sci Technolog Med Sci. 2009. PMID: 19821101 - Resistin: a hormone which induces insulin resistance is increased in normal pregnancy.
Nien JK, Mazaki-Tovi S, Romero R, Kusanovic JP, Erez O, Gotsch F, Pineles BL, Friel LA, Espinoza J, Goncalves L, Santolaya J, Gomez R, Hong JS, Edwin S, Soto E, Richani K, Mazor M, Hassan SS. Nien JK, et al. J Perinat Med. 2007;35(6):513-21. doi: 10.1515/JPM.2007.122. J Perinat Med. 2007. PMID: 17919114 Free PMC article. - [Adipokine update - new molecules, new functions].
Gelsinger C, Tschoner A, Kaser S, Ebenbichler CF. Gelsinger C, et al. Wien Med Wochenschr. 2010 Aug;160(15-16):377-90. doi: 10.1007/s10354-010-0781-6. Wien Med Wochenschr. 2010. PMID: 20812049 Review. German. - Serum resistin level in obese male children.
Amirhakimi A, Karamifar H, Moravej H, Amirhakimi G. Amirhakimi A, et al. J Obes. 2011;2011:953410. doi: 10.1155/2011/953410. Epub 2011 Mar 24. J Obes. 2011. PMID: 21603279 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical