Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population - PubMed (original) (raw)

doi: 10.2337/diabetes.51.2.536.

Philippe Boutin, Yasumichi Mori, Kazuyuki Tobe, Christian Dina, Kazuki Yasuda, Toshimasa Yamauchi, Shuichi Otabe, Terumasa Okada, Kazuhiro Eto, Hiroko Kadowaki, Ryoko Hagura, Yasuo Akanuma, Yoshio Yazaki, Ryozo Nagai, Matsuo Taniyama, Koichi Matsubara, Madoka Yoda, Yasuko Nakano, Motowo Tomita, Satoshi Kimura, Chikako Ito, Philippe Froguel, Takashi Kadowaki

Affiliations

• PMID: 11812766
• DOI: 10.2337/diabetes.51.2.536

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population

Kazuo Hara et al. Diabetes. 2002 Feb.

Erratum in

• Diabetes 2002 Apr;51(4):1294

Abstract

An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the adiponectin gene (APM1) is located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes (P = 0.003 and P = 0.002, respectively). Subjects with the G/G genotype at position 45 or the G/G genotype at position 276 had a significantly increased risk of type 2 diabetes (odds ratio 1.70 [95% CI 1.09-2.65] and 2.16 [1.22-3.95], respectively) compared with those having the T/T genotype at positions 45 and 276, respectively. In addition, the subjects with the G/G genotype at position 276 had a higher insulin resistance index than those with the T/T genotype (1.61 +/- 0.05 vs. 1.19 +/- 0.12, P = 0.001). The G allele at position 276 was linearly associated with lower plasma adiponectin levels (G/G: 10.4 +/- 0.85 microg/ml, G/T: 13.7 +/- 0.87 microg/ml, T/T: 16.6 +/- 2.24 microg/ml, P = 0.01) in subjects with higher BMIs. Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes.

PubMed Disclaimer

Similar articles

• Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes.
  Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F, Häring H. Stumvoll M, et al. Diabetes. 2002 Jan;51(1):37-41. doi: 10.2337/diabetes.51.1.37. Diabetes. 2002. PMID: 11756320
• Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects.
  Nakatani K, Noma K, Nishioka J, Kasai Y, Morioka K, Katsuki A, Hori Y, Yano Y, Sumida Y, Wada H, Nobori T. Nakatani K, et al. Int J Mol Med. 2005 Jan;15(1):173-7. Int J Mol Med. 2005. PMID: 15583845
• Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.
  Gu HF, Abulaiti A, Ostenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S. Gu HF, et al. Diabetes. 2004 Feb;53 Suppl 1:S31-5. doi: 10.2337/diabetes.53.2007.s31. Diabetes. 2004. PMID: 14749263
• The genetics of adiponectin.
  Vasseur F, Leprêtre F, Lacquemant C, Froguel P. Vasseur F, et al. Curr Diab Rep. 2003 Apr;3(2):151-8. doi: 10.1007/s11892-003-0039-4. Curr Diab Rep. 2003. PMID: 12728641 Review.
• [Adiponectin: a new adipocytokine].
  Lebas E, Paquot N, Scheen AJ. Lebas E, et al. Rev Med Liege. 2003 Sep;58(9):554-8. Rev Med Liege. 2003. PMID: 14626649 Review. French.

Cited by

• Adiponectin Gene Polymorphisms: A Case-Control Study on Their Role in Late-Onset Alzheimer's Disease Risk.
  Javor J, Ďurmanová V, Klučková K, Párnická Z, Radošinská D, Šutovský S, Vašečková B, Režnáková V, Králová M, Gmitterová K, Zorad Š, Shawkatová I. Javor J, et al. Life (Basel). 2024 Mar 7;14(3):346. doi: 10.3390/life14030346. Life (Basel). 2024. PMID: 38541671 Free PMC article.
• Association of Adiponectin 45T/G (rs2241766) and Visfatin 4689G/T (rs2110385) Gene Polymorphisms with Susceptibility to Obesity.
  Ghazizadeh F, Afshari-Moez S, Alinaghian N, Torab M, Rahimi-Moghaddam P. Ghazizadeh F, et al. Int J Prev Med. 2023 Sep 28;14:115. doi: 10.4103/ijpvm.ijpvm_79_22. eCollection 2023. Int J Prev Med. 2023. PMID: 38264564 Free PMC article.
• The Polymorphism rs17300539 in the Adiponectin Promoter Gene Is Related to Metabolic Syndrome, Insulin Resistance, and Adiponectin Levels in Caucasian Patients with Obesity.
  de Luis Roman D, Izaola Jauregui O, Primo Martin D. de Luis Roman D, et al. Nutrients. 2023 Dec 7;15(24):5028. doi: 10.3390/nu15245028. Nutrients. 2023. PMID: 38140287 Free PMC article.
• Role and mechanism of PVN-sympathetic-adipose circuit in depression and insulin resistance induced by chronic stress.
  Wang J, Sun L, You J, Peng H, Yan H, Wang J, Sun F, Cui M, Wang S, Zhang Z, Fan X, Liu D, Liu C, Qiu C, Chen C, Xu Z, Chen J, Li W, Liu B. Wang J, et al. EMBO Rep. 2023 Dec 6;24(12):e57176. doi: 10.15252/embr.202357176. Epub 2023 Oct 23. EMBO Rep. 2023. PMID: 37870400 Free PMC article.
• Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome.
  Butnariu LI, Gorduza EV, Țarcă E, Pânzaru MC, Popa S, Stoleriu S, Lupu VV, Lupu A, Cojocaru E, Trandafir LM, Moisă ȘM, Florea A, Stătescu L, Bădescu MC. Butnariu LI, et al. Diagnostics (Basel). 2023 Jul 12;13(14):2348. doi: 10.3390/diagnostics13142348. Diagnostics (Basel). 2023. PMID: 37510094 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal