Nutritional effects of cyclodextrins on liver and serum lipids and cecal organic acids in rats - PubMed (original) (raw)
Nutritional effects of cyclodextrins on liver and serum lipids and cecal organic acids in rats
S Kaewprasert et al. J Nutr Sci Vitaminol (Tokyo). 2001 Oct.
Abstract
The effect of dietary cyclodextrins on liver and serum lipids and cecal organic acid production was investigated. Male Wistar rats were fed a basal diet and a diet containing 5% of alpha-, beta-, or gamma-cyclodextrin. The body weight gain in rats fed the alpha-cyclodextrin diet was not significantly different from rats fed the other three kinds of diets. The feeding of dietary alpha-cyclodextrin increased total lipid and phospholipids in the liver. Beta-cyclodextrin significantly lowered serum total cholesterol and phospholipid levels compared with the basal diet et al. A decrease in serum triacylglycerol levels was also observed in beta-cyclodextrin-fed rats. Dietary alpha-cyclodextrin significantly increased the weight of cecal tissues and contents, and an approximate fourfold increase in acetate, propionate, and total organic acids was noted, indicating the fermentibility of beta-cyclodextrin compared with the basal diet. It seems likely that the suppression of serum cholesterol levels by alpha- and beta-cyclodextrins might be due to the increasing acetate and propionate productions in the cecum. cecal organic acid, cyclodextrin, serum cholesterol, rats
Similar articles
- Role of dietary propionic acid and bile acid excretion in the hypocholesterolemic effects of oligosaccharides in rats.
Levrat MA, Favier ML, Moundras C, Rémésy C, Demigné C, Morand C. Levrat MA, et al. J Nutr. 1994 Apr;124(4):531-8. doi: 10.1093/jn/124.4.531. J Nutr. 1994. PMID: 8145075 - Effect of cyclodextrin on plasma lipids and cholesterol metabolism in the rat.
Favier ML, Rémésy C, Moundras C, Demigné C. Favier ML, et al. Metabolism. 1995 Feb;44(2):200-6. doi: 10.1016/0026-0495(95)90265-1. Metabolism. 1995. PMID: 7869916 - Cyclodextrins: Potential therapeutics against atherosclerosis.
Mahjoubin-Tehran M, Kovanen PT, Xu S, Jamialahmadi T, Sahebkar A. Mahjoubin-Tehran M, et al. Pharmacol Ther. 2020 Oct;214:107620. doi: 10.1016/j.pharmthera.2020.107620. Epub 2020 Jun 26. Pharmacol Ther. 2020. PMID: 32599008 Review. - Cyclodextrins as therapeutic drugs for treating lipid metabolism disorders.
Wu J, Li J, Shao W, Hu Y, Chen H, Chen Y, Chen Y, Liu Q, Ao M. Wu J, et al. Obes Rev. 2024 Apr;25(4):e13687. doi: 10.1111/obr.13687. Epub 2024 Jan 10. Obes Rev. 2024. PMID: 38204297 Review.
Cited by
- Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure.
Sasaki D, Sasaki K, Ikuta N, Yasuda T, Fukuda I, Kondo A, Osawa R. Sasaki D, et al. Sci Rep. 2018 Jan 11;8(1):435. doi: 10.1038/s41598-017-18877-8. Sci Rep. 2018. PMID: 29323180 Free PMC article. - Dietary α-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice.
Sakurai T, Sakurai A, Chen Y, Vaisman BL, Amar MJ, Pryor M, Thacker SG, Zhang X, Wang X, Zhang Y, Zhu J, Yang ZH, Freeman LA, Remaley AT. Sakurai T, et al. Mol Nutr Food Res. 2017 Aug;61(8):10.1002/mnfr.201600804. doi: 10.1002/mnfr.201600804. Epub 2017 Feb 24. Mol Nutr Food Res. 2017. PMID: 28102587 Free PMC article. - A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts.
Shirao S, Yoneda H, Shinoyama M, Sugimoto K, Koizumi H, Ishihara H, Oka F, Sadahiro H, Nomura S, Fujii M, Tamechika M, Kagawa Y, Owada Y, Suzuki M. Shirao S, et al. J Cereb Blood Flow Metab. 2015 May;35(5):835-42. doi: 10.1038/jcbfm.2014.260. Epub 2015 Jan 21. J Cereb Blood Flow Metab. 2015. PMID: 25605290 Free PMC article. - The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer.
Kaczmarczyk MM, Miller MJ, Freund GG. Kaczmarczyk MM, et al. Metabolism. 2012 Aug;61(8):1058-66. doi: 10.1016/j.metabol.2012.01.017. Epub 2012 Mar 7. Metabolism. 2012. PMID: 22401879 Free PMC article. Review. - Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids.
Amar MJ, Kaler M, Courville AB, Shamburek R, Sampson M, Remaley AT. Amar MJ, et al. Lipids Health Dis. 2016 Jul 12;15(1):115. doi: 10.1186/s12944-016-0284-6. Lipids Health Dis. 2016. PMID: 27405337 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources