A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain - PubMed (original) (raw)
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
Chester A Mathis et al. Bioorg Med Chem Lett. 2002.
Abstract
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.
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