Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease - PubMed (original) (raw)

Review

Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

J C Morris et al. J Mol Neurosci. 2001 Oct.

Abstract

The results of studies from the Washington University Alzheimer Disease (AD) Research Center and those from other centers and investigators regarding the neuropathologic correlates of normal aging and early-stage AD are reviewed. We conclude that widespread amyloid plaques in the neocortex best distinguishes very early stage AD, including "MCI" stage, and preclinical stages, from healthy brain aging. Other AD lesions, including increased formation of neurofibrillary tangles and neuronal degeneration appear to result from the amyloid-initiated pathologic process, although they may have a more immediate effect on expression and severity of dementia. These data provide strong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life.

PubMed Disclaimer

References

    1. Neurology. 1996 Jan;46(1):149-54 - PubMed
    1. Br J Psychiatry. 1968 Jul;114(512):797-811 - PubMed
    1. Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S1-2 - PubMed
    1. Arch Pathol Lab Med. 1993 Feb;117(2):129-31 - PubMed
    1. JAMA. 1999 Jul 7;282(1):40-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources