E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis - PubMed (original) (raw)

. 2002 Jan 17;21(3):437-46.

doi: 10.1038/sj.onc.1205102.

Affiliations

• PMID: 11821956
• DOI: 10.1038/sj.onc.1205102

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

Shirley Polager et al. Oncogene. 2002.

Abstract

The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data indicate that E2F up-regulates the expression of genes not previously described as E2F target genes. A number of these E2F-regulated genes are involved in DNA replication, DNA repair and mitosis. These results suggest that E2F affects cell cycle progression both at S phase and during mitosis. Furthermore, our findings indicate that E2F-dependent gene activation may contribute to the cellular response to DNA damage.

PubMed Disclaimer

Similar articles

• Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.
  Kalma Y, Marash L, Lamed Y, Ginsberg D. Kalma Y, et al. Oncogene. 2001 Mar 15;20(11):1379-87. doi: 10.1038/sj.onc.1204230. Oncogene. 2001. PMID: 11313881
• Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly.
  van der Meijden CM, Lapointe DS, Luong MX, Peric-Hupkes D, Cho B, Stein JL, van Wijnen AJ, Stein GS. van der Meijden CM, et al. Cancer Res. 2002 Jun 1;62(11):3233-43. Cancer Res. 2002. PMID: 12036939
• Poly(ADP-ribose) polymerase upregulates E2F-1 promoter activity and DNA pol alpha expression during early S phase.
  Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Smulson ME. Simbulan-Rosenthal CM, et al. Oncogene. 1999 Sep 9;18(36):5015-23. doi: 10.1038/sj.onc.1202900. Oncogene. 1999. PMID: 10490838
• E2F target genes: unraveling the biology.
  Bracken AP, Ciro M, Cocito A, Helin K. Bracken AP, et al. Trends Biochem Sci. 2004 Aug;29(8):409-17. doi: 10.1016/j.tibs.2004.06.006. Trends Biochem Sci. 2004. PMID: 15362224 Review.
• [RB/E2F regulation of DNA replication and genomic stability].
  Ohtani K, Eiko O. Ohtani K, et al. Tanpakushitsu Kakusan Koso. 2009 Mar;54(4 Suppl):327-33. Tanpakushitsu Kakusan Koso. 2009. PMID: 21089471 Review. Japanese. No abstract available.

Cited by

• A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.
  Buttitta LA, Katzaroff AJ, Edgar BA. Buttitta LA, et al. J Cell Biol. 2010 Jun 14;189(6):981-96. doi: 10.1083/jcb.200910006. J Cell Biol. 2010. PMID: 20548101 Free PMC article.
• pRb-Independent growth arrest and transcriptional regulation of E2F target genes.
  McCabe MT, Azih OJ, Day ML. McCabe MT, et al. Neoplasia. 2005 Feb;7(2):141-51. doi: 10.1593/neo.04394. Neoplasia. 2005. PMID: 15802019 Free PMC article.
• The MPS1 family of protein kinases.
  Liu X, Winey M. Liu X, et al. Annu Rev Biochem. 2012;81:561-85. doi: 10.1146/annurev-biochem-061611-090435. Epub 2012 Apr 5. Annu Rev Biochem. 2012. PMID: 22482908 Free PMC article. Review.
• E2F1: Cause and Consequence of DNA Replication Stress.
  Fouad S, Hauton D, D'Angiolella V. Fouad S, et al. Front Mol Biosci. 2021 Feb 16;7:599332. doi: 10.3389/fmolb.2020.599332. eCollection 2020. Front Mol Biosci. 2021. PMID: 33665206 Free PMC article. Review.
• Transcriptional control of mitosis: deregulation and cancer.
  Nath S, Ghatak D, Das P, Roychoudhury S. Nath S, et al. Front Endocrinol (Lausanne). 2015 May 5;6:60. doi: 10.3389/fendo.2015.00060. eCollection 2015. Front Endocrinol (Lausanne). 2015. PMID: 25999914 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group