Volume changes in gray matter in patients with schizophrenia - PubMed (original) (raw)
Volume changes in gray matter in patients with schizophrenia
Hilleke E Hulshoff Pol et al. Am J Psychiatry. 2002 Feb.
Abstract
Objective: Schizophrenia is generally characterized by a progressive decline in functioning. Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time.
Method: Magnetic resonance brain images from 159 patients with schizophrenia and 158 healthy comparison subjects between 16 and 70 years of age were compared. Using linear regression analysis, the authors analyzed the relationship between the volumes of the total brain, gray and white matter, cerebellum, and lateral and third ventricles with patient age.
Results: Total brain (-2.2%), cerebral gray matter (-3.3%), prefrontal gray matter (-4.4%), and prefrontal white matter (-3.5%) volumes were smaller, and lateral (27%) and third (30%) ventricle and peripheral CSF (11%) volumes were larger in schizophrenia patients. A significant group-by-age interaction for gray matter volume was found, as shown by a steeper regression slope between age and gray matter volume in patients (-3.43 ml/year) than in healthy comparison subjects (-2.74 ml/year).
Conclusions: The smaller brains of the patients with schizophrenia can be explained by decreases in gray matter volume. Moreover, the finding that the smaller gray matter volume was more pronounced in older patients with schizophrenia may suggest progressive loss of cerebral gray matter in schizophrenia patients.
Similar articles
- Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study.
Yamasue H, Iwanami A, Hirayasu Y, Yamada H, Abe O, Kuroki N, Fukuda R, Tsujii K, Aoki S, Ohtomo K, Kato N, Kasai K. Yamasue H, et al. Psychiatry Res. 2004 Sep 15;131(3):195-207. doi: 10.1016/j.pscychresns.2004.05.004. Psychiatry Res. 2004. PMID: 15465289 - MRI assessment of gray and white matter distribution in Brodmann's areas of the cortex in patients with schizophrenia with good and poor outcomes.
Mitelman SA, Shihabuddin L, Brickman AM, Hazlett EA, Buchsbaum MS. Mitelman SA, et al. Am J Psychiatry. 2003 Dec;160(12):2154-68. doi: 10.1176/appi.ajp.160.12.2154. Am J Psychiatry. 2003. PMID: 14638586 - Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia.
Rüsch N, Spoletini I, Wilke M, Bria P, Di Paola M, Di Iulio F, Martinotti G, Caltagirone C, Spalletta G. Rüsch N, et al. Schizophr Res. 2007 Jul;93(1-3):79-89. doi: 10.1016/j.schres.2007.01.029. Epub 2007 Mar 26. Schizophr Res. 2007. PMID: 17383859 - Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.
Kuo SS, Pogue-Geile MF. Kuo SS, et al. Neurosci Biobehav Rev. 2019 Mar;98:85-94. doi: 10.1016/j.neubiorev.2018.12.030. Epub 2019 Jan 4. Neurosci Biobehav Rev. 2019. PMID: 30615934 Free PMC article. Review. - What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia.
Hulshoff Pol HE, Kahn RS. Hulshoff Pol HE, et al. Schizophr Bull. 2008 Mar;34(2):354-66. doi: 10.1093/schbul/sbm168. Epub 2008 Feb 17. Schizophr Bull. 2008. PMID: 18283048 Free PMC article. Review.
Cited by
- Transcriptomic and neuroimaging data integration enhances machine learning classification of schizophrenia.
Wang M, Zhao SW, Wu D, Zhang YH, Han YK, Zhao K, Qi T, Liu Y, Cui LB, Wei Y. Wang M, et al. Psychoradiology. 2024 Mar 26;4:kkae005. doi: 10.1093/psyrad/kkae005. eCollection 2024. Psychoradiology. 2024. PMID: 38694267 Free PMC article. - NBS-SNI, an extension of the network-based statistic: Abnormal functional connections between important structural actors.
Normand F, Gajwani M, Côté DC, Allard A. Normand F, et al. Netw Neurosci. 2024 Apr 1;8(1):44-80. doi: 10.1162/netn_a_00344. eCollection 2024. Netw Neurosci. 2024. PMID: 38562286 Free PMC article. - Tract-based analyses of white matter in schizophrenia, bipolar disorder, aging, and dementia using high spatial and directional resolution diffusion imaging: a pilot study.
Mamah D, Chen S, Shimony JS, Harms MP. Mamah D, et al. Front Psychiatry. 2024 Feb 1;15:1240502. doi: 10.3389/fpsyt.2024.1240502. eCollection 2024. Front Psychiatry. 2024. PMID: 38362028 Free PMC article. - Low-dose lithium adjunct to atypical antipsychotic treatment nearly improved cognitive impairment, deteriorated the gray-matter volume, and decreased the interleukin-6 level in drug-naive patients with first schizophrenia symptoms: a follow-up pilot study.
Zhuo C, Hu S, Chen G, Yang L, Cai Z, Tian H, Jiang D, Chen C, Wang L, Ma X, Li R. Zhuo C, et al. Schizophrenia (Heidelb). 2023 Oct 14;9(1):71. doi: 10.1038/s41537-023-00400-w. Schizophrenia (Heidelb). 2023. PMID: 37838729 Free PMC article. - Brain age prediction across the human lifespan using multimodal MRI data.
Guan S, Jiang R, Meng C, Biswal B. Guan S, et al. Geroscience. 2024 Feb;46(1):1-20. doi: 10.1007/s11357-023-00924-0. Epub 2023 Sep 21. Geroscience. 2024. PMID: 37733220 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical