Quantitative and qualitative adjustment of thymic T cell production by clonal expansion of premigrant thymocytes - PubMed (original) (raw)
Comparative Study
. 2002 Feb 15;168(4):1664-71.
doi: 10.4049/jimmunol.168.4.1664.
Affiliations
- PMID: 11823495
- DOI: 10.4049/jimmunol.168.4.1664
Comparative Study
Quantitative and qualitative adjustment of thymic T cell production by clonal expansion of premigrant thymocytes
Armelle Le Campion et al. J Immunol. 2002.
Abstract
In normal mice, single-positive thymocytes proliferate before being exported into the peripheral T cell pool. We measured the in vivo proliferation rates of mature thymocytes in several TCR transgenic mice. Different monoclonal TCR transgenic single-positive thymocytes proliferated at different rates in a given MHC context. Conversely, mature thymocytes expressing a given TCR, generated in mice of different MHC haplotypes, also showed different rates of proliferation. In p59(fyn)-deficient mice, the proliferation rate of mature thymocytes was diminished. Thus, premigrant thymocyte expansion is TCR mediated and depends on TCR affinity for self peptide/MHC ligands. In addition, we show that mature thymocyte expansion is clonotypic, increases the daily thymic T cell output, and modifies the TCR repertoire of newly produced T cells.
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