Sibling rivalry in the E2F family - PubMed (original) (raw)
Review
doi: 10.1038/nrm714.
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- PMID: 11823794
- DOI: 10.1038/nrm714
Review
Sibling rivalry in the E2F family
Jeffrey M Trimarchi et al. Nat Rev Mol Cell Biol. 2002 Jan.
Abstract
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
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