Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation - PubMed (original) (raw)

doi: 10.1038/ni763. Epub 2002 Feb 4.

Affiliations

• PMID: 11828324
• DOI: 10.1038/ni763

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

Deyu Fang et al. Nat Immunol. 2002 Mar.

Abstract

Itch is an E3 ubiquitin ligase that is disrupted in nonagouti-lethal or itchy mice. Itch deficiency leads to severe immune and inflammatory disorders and constant itching of the skin. Here we show that Itchminus sign/minus sign T cells show an activated phenotype and enhanced proliferation. Production of the type 2 T helper (TH2) cell cytokines interleukin 4 (IL-4) and IL-5 by Itchminus sign/minus sign T cells was augmented upon stimulation, and the TH2-dependent serum concentrations of immunoglobulin G1 (IgG1) and IgE in itchy mice were also increased. Molecularly, Itch associated with and induced ubiquitination of JunB, a transcription factor that is involved in TH2 differentiation. These results provide a molecular link between Itch deficiency and the aberrant activation of immune responses in itchy mice.

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Comment in

• Antigen receptors rap to integrin receptors.
  Abraham RT. Abraham RT. Nat Immunol. 2002 Mar;3(3):212-3. doi: 10.1038/ni0302-212. Nat Immunol. 2002. PMID: 11875457 No abstract available.

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