Apoptosis: a link between cancer genetics and chemotherapy - PubMed (original) (raw)

Review

. 2002 Jan 25;108(2):153-64.

doi: 10.1016/s0092-8674(02)00625-6.

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Free article

Review

Ricky W Johnstone et al. Cell. 2002.

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Abstract

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

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