Impairment of immunological memory in the absence of MHC despite survival of memory T cells - PubMed (original) (raw)
doi: 10.1038/ni766. Epub 2002 Feb 11.
Affiliations
- PMID: 11836529
- DOI: 10.1038/ni766
Impairment of immunological memory in the absence of MHC despite survival of memory T cells
George Kassiotis et al. Nat Immunol. 2002 Mar.
Abstract
The mechanisms by which immunological memory is maintained after infection or vaccination are still a matter of debate. Long-term survival of memory T cells does not require major histocompatibility complex (MHC) contact. We show here that compared with memory CD4+ T cells that maintain contact with MHC class II, memory CD4+ T cells deprived of MHC class II contact show distinct functional defects upon antigen re-encounter. Thus, in contrast to their survival, maintenance of the typical quality of memory T cells crucially depends on MHC-derived signals.
Comment in
- Requirements for memory maintenance.
Rocha B. Rocha B. Nat Immunol. 2002 Mar;3(3):209-10. doi: 10.1038/ni0302-209. Nat Immunol. 2002. PMID: 11875455 No abstract available.
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