wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila - PubMed (original) (raw)
wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila
Hermann Aberle et al. Neuron. 2002.
Free article
Abstract
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evoked excitatory junctional potentials, decreased levels of the synaptic cell adhesion molecule Fasciclin II, and synaptic membrane detachment at active zones. Wit is expressed by a subset of neurons, including motoneurons. The NMJ phenotype is specifically rescued by transgenic expression of Wit only in motoneurons. Thus, Wit appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ.
Comment in
- Is synaptic homeostasis just wishful thinking?
Keshishian H. Keshishian H. Neuron. 2002 Feb 14;33(4):491-2. doi: 10.1016/s0896-6273(02)00597-4. Neuron. 2002. PMID: 11856522 Review. - Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ.
Fuentes-Medel Y, Budnik V. Fuentes-Medel Y, et al. Neuron. 2010 May 27;66(4):473-5. doi: 10.1016/j.neuron.2010.05.016. Neuron. 2010. PMID: 20510851 Free PMC article.
Similar articles
- The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function.
Marqués G, Bao H, Haerry TE, Shimell MJ, Duchek P, Zhang B, O'Connor MB. Marqués G, et al. Neuron. 2002 Feb 14;33(4):529-43. doi: 10.1016/s0896-6273(02)00595-0. Neuron. 2002. PMID: 11856528 - Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins.
Zhao G, Wu Y, Du L, Li W, Xiong Y, Yao A, Wang Q, Zhang YQ. Zhao G, et al. PLoS Genet. 2015 Mar 6;11(3):e1004984. doi: 10.1371/journal.pgen.1004984. eCollection 2015 Mar. PLoS Genet. 2015. PMID: 25748449 Free PMC article. - The Ly6 neurotoxin-like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila.
Kim NC, Marqués G. Kim NC, et al. Dev Neurobiol. 2012 Dec;72(12):1541-58. doi: 10.1002/dneu.22021. Epub 2012 Jul 27. Dev Neurobiol. 2012. PMID: 22467519 - Is synaptic homeostasis just wishful thinking?
Keshishian H. Keshishian H. Neuron. 2002 Feb 14;33(4):491-2. doi: 10.1016/s0896-6273(02)00597-4. Neuron. 2002. PMID: 11856522 Review. - Development and plasticity of the Drosophila larval neuromuscular junction.
Menon KP, Carrillo RA, Zinn K. Menon KP, et al. Wiley Interdiscip Rev Dev Biol. 2013 Sep-Oct;2(5):647-70. doi: 10.1002/wdev.108. Epub 2013 Feb 5. Wiley Interdiscip Rev Dev Biol. 2013. PMID: 24014452 Free PMC article. Review.
Cited by
- Tissue-specific knockout in the Drosophila neuromuscular system reveals ESCRT's role in formation of synapse-derived extracellular vesicles.
Chen X, Perry S, Fan Z, Wang B, Loxterkamp E, Wang S, Hu J, Dickman D, Han C. Chen X, et al. PLoS Genet. 2024 Oct 10;20(10):e1011438. doi: 10.1371/journal.pgen.1011438. eCollection 2024 Oct. PLoS Genet. 2024. PMID: 39388480 Free PMC article. - Presynaptic structural and functional plasticity are coupled by convergent Rap1 signaling.
Kim YD, Park HG, Song S, Kim J, Lee BJ, Broadie K, Lee S. Kim YD, et al. J Cell Biol. 2024 Jul 1;223(7):e202309095. doi: 10.1083/jcb.202309095. Epub 2024 May 15. J Cell Biol. 2024. PMID: 38748250 Free PMC article. - Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses.
DePew AT, Bruckner JJ, O'Connor-Giles KM, Mosca TJ. DePew AT, et al. Development. 2024 Jun 1;151(11):dev202517. doi: 10.1242/dev.202517. Epub 2024 Jun 3. Development. 2024. PMID: 38738619 Free PMC article. - Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles.
von Saucken VE, Windner SE, Baylies MK. von Saucken VE, et al. bioRxiv [Preprint]. 2024 Apr 11:2024.04.10.588944. doi: 10.1101/2024.04.10.588944. bioRxiv. 2024. PMID: 38645063 Free PMC article. Preprint. - Bone morphogenetic protein signaling: the pathway and its regulation.
Akiyama T, Raftery LA, Wharton KA. Akiyama T, et al. Genetics. 2024 Feb 7;226(2):iyad200. doi: 10.1093/genetics/iyad200. Genetics. 2024. PMID: 38124338 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous