Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex - PubMed (original) (raw)
Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex
Martine Hamann et al. Neuron. 2002.
Free article
Abstract
We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABA(A) receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.
Similar articles
- GABA spillover from single inhibitory axons suppresses low-frequency excitatory transmission at the cerebellar glomerulus.
Mitchell SJ, Silver RA. Mitchell SJ, et al. J Neurosci. 2000 Dec 1;20(23):8651-8. doi: 10.1523/JNEUROSCI.20-23-08651.2000. J Neurosci. 2000. PMID: 11102470 Free PMC article. - Cerebellar cortex: computation by extrasynaptic inhibition?
De Schutter E. De Schutter E. Curr Biol. 2002 May 14;12(10):R363-5. doi: 10.1016/s0960-9822(02)00861-8. Curr Biol. 2002. PMID: 12015139 - Multiple modes of GABAergic inhibition of rat cerebellar granule cells.
Rossi DJ, Hamann M, Attwell D. Rossi DJ, et al. J Physiol. 2003 Apr 1;548(Pt 1):97-110. doi: 10.1113/jphysiol.2002.036459. Epub 2003 Feb 14. J Physiol. 2003. PMID: 12588900 Free PMC article. - Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors.
Farrant M, Nusser Z. Farrant M, et al. Nat Rev Neurosci. 2005 Mar;6(3):215-29. doi: 10.1038/nrn1625. Nat Rev Neurosci. 2005. PMID: 15738957 Review. - Helping thy neighbors: spillover at the mossy fiber glomerulus.
Otis T. Otis T. Neuron. 2002 Aug 1;35(3):412-4. doi: 10.1016/s0896-6273(02)00796-1. Neuron. 2002. PMID: 12165464 Review.
Cited by
- Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.
Hashemi M, Hutt A, Sleigh J. Hashemi M, et al. Front Syst Neurosci. 2014 Dec 10;8:232. doi: 10.3389/fnsys.2014.00232. eCollection 2014. Front Syst Neurosci. 2014. PMID: 25540612 Free PMC article. - NMDA receptors with incomplete Mg²⁺ block enable low-frequency transmission through the cerebellar cortex.
Schwartz EJ, Rothman JS, Dugué GP, Diana M, Rousseau C, Silver RA, Dieudonné S. Schwartz EJ, et al. J Neurosci. 2012 May 16;32(20):6878-93. doi: 10.1523/JNEUROSCI.5736-11.2012. J Neurosci. 2012. PMID: 22593057 Free PMC article. - Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.
Duguid I, Branco T, London M, Chadderton P, Häusser M. Duguid I, et al. J Neurosci. 2012 Aug 8;32(32):11132-43. doi: 10.1523/JNEUROSCI.0460-12.2012. J Neurosci. 2012. PMID: 22875944 Free PMC article. - Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice.
Shimuta M, Sugihara I, Ishikawa T. Shimuta M, et al. Commun Biol. 2020 Jul 15;3(1):381. doi: 10.1038/s42003-020-1110-2. Commun Biol. 2020. PMID: 32669638 Free PMC article. - Extrasynaptic GABAA receptors: form, pharmacology, and function.
Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW. Belelli D, et al. J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009. J Neurosci. 2009. PMID: 19828786 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources