NKT cells - conductors of tumor immunity? - PubMed (original) (raw)

Review

NKT cells - conductors of tumor immunity?

Mark J Smyth et al. Curr Opin Immunol. 2002 Apr.

Abstract

NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or alpha-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.

PubMed Disclaimer

Similar articles

• Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells.
  van der Vliet HJ, Molling JW, Nishi N, Masterson AJ, Kölgen W, Porcelli SA, van den Eertwegh AJ, von Blomberg BM, Pinedo HM, Giaccone G, Scheper RJ. van der Vliet HJ, et al. Cancer Res. 2003 Jul 15;63(14):4101-6. Cancer Res. 2003. PMID: 12874013
• Tumor cells loaded with alpha-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice.
  Shimizu K, Goto A, Fukui M, Taniguchi M, Fujii S. Shimizu K, et al. J Immunol. 2007 Mar 1;178(5):2853-61. doi: 10.4049/jimmunol.178.5.2853. J Immunol. 2007. PMID: 17312129
• The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.
  Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nishimura T. Kitamura H, et al. J Exp Med. 1999 Apr 5;189(7):1121-8. doi: 10.1084/jem.189.7.1121. J Exp Med. 1999. PMID: 10190903 Free PMC article.
• Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity.
  Fujii S, Shimizu K, Hemmi H, Steinman RM. Fujii S, et al. Immunol Rev. 2007 Dec;220:183-98. doi: 10.1111/j.1600-065X.2007.00561.x. Immunol Rev. 2007. PMID: 17979847 Review.
• Valpha14 NKT cell-mediated anti-tumor responses and their clinical application.
  Seino K, Fujii S, Harada M, Motohashi S, Nakayama T, Fujisawa T, Taniguchi M. Seino K, et al. Springer Semin Immunopathol. 2005 Jun;27(1):65-74. doi: 10.1007/s00281-004-0194-y. Epub 2005 Jan 14. Springer Semin Immunopathol. 2005. PMID: 15650847 Review.

Cited by

• Natural killer T cells are targets for human immunodeficiency virus infection.
  Crowe NY, Godfrey DI, Baxter AG. Crowe NY, et al. Immunology. 2003 Jan;108(1):1-2. doi: 10.1046/j.1365-2567.2003.01580.x. Immunology. 2003. PMID: 12519295 Free PMC article. No abstract available.
• Natural killer T-cell populations in C57BL/6 and NK1.1 congenic BALB.NK mice-a novel thymic subset defined in BALB.NK mice.
  Stenström M, Sköld M, Andersson A, Cardell SL. Stenström M, et al. Immunology. 2005 Mar;114(3):336-45. doi: 10.1111/j.1365-2567.2004.02111.x. Immunology. 2005. PMID: 15720435 Free PMC article.
• Cross-regulation between distinct natural killer T cell subsets influences immune response to self and foreign antigens.
  Arrenberg P, Halder R, Kumar V. Arrenberg P, et al. J Cell Physiol. 2009 Feb;218(2):246-50. doi: 10.1002/jcp.21597. J Cell Physiol. 2009. PMID: 18814145 Free PMC article. Review.
• License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity.
  Díaz-Basabe A, Strati F, Facciotti F. Díaz-Basabe A, et al. Int J Mol Sci. 2020 May 30;21(11):3909. doi: 10.3390/ijms21113909. Int J Mol Sci. 2020. PMID: 32486268 Free PMC article. Review.
• Oral Administration of Silk Peptide Enhances the Maturation and Cytolytic Activity of Natural Killer Cells.
  Jang SH, Oh MS, Baek HI, Ha KC, Lee JY, Jang YS. Jang SH, et al. Immune Netw. 2018 Oct 26;18(5):e37. doi: 10.4110/in.2018.18.e37. eCollection 2018 Oct. Immune Netw. 2018. PMID: 30402332 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database