On the brink of becoming a T cell - PubMed (original) (raw)

Review

On the brink of becoming a T cell

Christine Borowski et al. Curr Opin Immunol. 2002 Apr.

Abstract

Recent studies provide fresh insight into the mechanisms by which precursor cells are committed to and develop within the T-lymphocyte lineage. Precursor/product studies have identified developmental stages between that of the pluripotent hematopoietic stem cell and thymocytes committed to the T lineage. Specific ligands and signaling pathways interacting with the Notch-1 receptor and its ability to influence commitment within the lymphoid lineage have been described. Although the structural features or putative ligands endowing the pre-TCR with constitutive signaling capacity remain elusive, numerous distal mediators of pre-TCR signaling have been identified. It remains for the future to determine what roles they may have in survival, proliferation, lineage commitment and allelic exclusion of TCR genes. Receptor editing and lineage commitment of alphabeta T cells still represent controversial topics that need further study.

PubMed Disclaimer

Cited by

Progression of regulatory gene expression states in fetal and adult pro-T-cell development.
David-Fung ES, Yui MA, Morales M, Wang H, Taghon T, Diamond RA, Rothenberg EV. David-Fung ES, et al. Immunol Rev. 2006 Feb;209:212-36. doi: 10.1111/j.0105-2896.2006.00355.x. Immunol Rev. 2006. PMID: 16448545 Free PMC article. Review.
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.
Franco CB, Scripture-Adams DD, Proekt I, Taghon T, Weiss AH, Yui MA, Adams SL, Diamond RA, Rothenberg EV. Franco CB, et al. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11993-8. doi: 10.1073/pnas.0601188103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880393 Free PMC article.
Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling.
Zeng LH, Barkat MQ, Syed SK, Shah S, Abbas G, Xu C, Mahdy A, Hussain N, Hussain L, Majeed A, Khan KU, Wu X, Hussain M. Zeng LH, et al. Cells. 2022 May 28;11(11):1774. doi: 10.3390/cells11111774. Cells. 2022. PMID: 35681469 Free PMC article. Review.
Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.
Croom HA, Izon DJ, Chong MM, Curtis DJ, Roberts AW, Kay TW, Hilton DJ, Alexander WS, Starr R. Croom HA, et al. Mol Immunol. 2008 May;45(10):2888-96. doi: 10.1016/j.molimm.2008.01.024. Epub 2008 Mar 5. Mol Immunol. 2008. PMID: 18321577 Free PMC article.
Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.
Miletic AV, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Gomez TS, Ota N, Kloeppel T, Kanagawa O, Tokunaga M, Billadeau DD, Swat W. Miletic AV, et al. J Biol Chem. 2006 Dec 15;281(50):38257-65. doi: 10.1074/jbc.M608913200. Epub 2006 Oct 18. J Biol Chem. 2006. PMID: 17050525 Free PMC article.

On the brink of becoming a T cell - PubMed (original) (raw)