Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia - PubMed (original) (raw)
. 2002 Mar 15;99(6):2262-4.
doi: 10.1182/blood.v99.6.2262.
Ulf Thunberg, Anna Johnson, Ingrid Thörn, Ola Söderberg, Magnus Hultdin, Johan Botling, Gunilla Enblad, Jan Sällström, Christer Sundström, Göran Roos, Richard Rosenquist
Affiliations
- PMID: 11877310
- DOI: 10.1182/blood.v99.6.2262
Free article
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
Gerard Tobin et al. Blood. 2002.
Free article
Abstract
Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the V(H)3-21 gene in mutated cases, whereas biased V(H)1-69 gene usage was found in unmutated cases as previously reported. Interestingly, the subset of mutated cases using the V(H)3-21 gene displayed distinctive genotypic/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of lambda light chains. In addition, this mutated subset showed significantly shorter survival than other mutated cases and a similar clinical course to unmutated cases. We therefore suggest that B-CLL cases with mutated V(H)3-21 genes may constitute an additional entity of B-CLL.
Comment in
- Do B-cell chronic lymphocytic leukemia patients with Ig VH3-21 genes constitute a new subset of chronic lymphocytic leukemia?
Nollet F, Cauwelier B, Billiet J, Selleslag D, Van Hoof A, Louwagie A, Criel A. Nollet F, et al. Blood. 2002 Aug 1;100(3):1097-8; author reply 1098-9. doi: 10.1182/blood-2002-03-0867. Blood. 2002. PMID: 12130479 No abstract available. - High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment.
Lin K, Manocha S, Harris RJ, Matrai Z, Sherrington PD, Pettitt AR. Lin K, et al. Blood. 2003 Aug 1;102(3):1145-6. doi: 10.1182/blood-2003-04-1289. Blood. 2003. PMID: 12869492 No abstract available.
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