An antibody that prevents the hemagglutinin low pH fusogenic transition - PubMed (original) (raw)

. 2002 Mar 1;294(1):70-4.

doi: 10.1006/viro.2001.1320.

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• PMID: 11886266
• DOI: 10.1006/viro.2001.1320

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An antibody that prevents the hemagglutinin low pH fusogenic transition

C Barbey-Martin et al. Virology. 2002.

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Abstract

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

(C)2002 Elsevier Science (USA).

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