Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents - PubMed (original) (raw)
Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents
Mauricette Brocco et al. Pharmacol Biochem Behav. 2002 Apr.
Abstract
This study characterized the influence of acute administration of diverse classes of antidepressant agent upon the spontaneous locomotor activity (LA) of mice in a novel, open-field environment. The selective serotonin (5-HT) reuptake inhibitors (SSRIs), citalopram, fluoxetine, paroxetine, fluvoxamine, litoxetine and zimelidine, dose-dependently enhanced LA. Their actions were mimicked by the mixed 5-HT/noradrenaline (NA) reuptake inhibitors (SNRIs), venlafaxine, duloxetine and S33005. In contrast, clomipramine only slightly elevated LA and two further tricyclics, imipramine and amitriptyline, were inactive. Further, the selective NA vs. 5-HT reuptake inhibitors (NARIs), reboxetine, desipramine, maprotiline, nisoxetine and nortriptyline all failed to increase LA. The "atypical antidepressants," mianserin and mirtazapine, neither of which modify 5-HT reuptake, as well as the mixed SSRI/5-HT(2) antagonists, nefazodone and trazodone, also failed to increase LA. Doses of SSRI and SNRI which increased LA did not modify motor performance in the rotarod test. Further, they did not enhance LA in rats, suggesting that this response is characteristic of mice. Finally, upon prehabituation of mice to the activity chamber, the SSRI, citalopram, and the SNRI, venlafaxine, failed to increase LA. In conclusion, in mice exposed to a novel environment, inhibition of 5-HT reuptake by SSRIs and SNRIs enhances spontaneous LA in the absence of a generalized influence upon motor function. This response provides a simple parameter for characterization of SSRIs and SNRIs, and differentiates them from other classes of antidepressant agent. Although an influence upon arousal and/or anxiety is likely related to the increase in LA, the functional significance of this response requires additional elucidation.
Similar articles
- Differential modulation of efficiency in a food-rewarded "differential reinforcement of low-rate" 72-s schedule in rats by norepinephrine and serotonin reuptake inhibitors.
Dekeyne A, Gobert A, Auclair A, Girardon S, Millan MJ. Dekeyne A, et al. Psychopharmacology (Berl). 2002 Jul;162(2):156-67. doi: 10.1007/s00213-002-1070-x. Epub 2002 May 1. Psychopharmacology (Berl). 2002. PMID: 12110993 - S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
Millan MJ, Dekeyne A, Papp M, La Rochelle CD, MacSweeny C, Peglion JL, Brocco M. Millan MJ, et al. J Pharmacol Exp Ther. 2001 Aug;298(2):581-91. J Pharmacol Exp Ther. 2001. PMID: 11454919 - Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
Sánchez C, Hyttel J. Sánchez C, et al. Cell Mol Neurobiol. 1999 Aug;19(4):467-89. doi: 10.1023/a:1006986824213. Cell Mol Neurobiol. 1999. PMID: 10379421 Review. - Discriminative stimulus properties of antidepressant agents: a review.
Dekeyne A, Millan MJ. Dekeyne A, et al. Behav Pharmacol. 2003 Sep;14(5-6):391-407. doi: 10.1097/01.fbp.0000089141.24369.07. Behav Pharmacol. 2003. PMID: 14501253 Review.
Cited by
- Effects of short-term clomipramine on anxiety-like behavior, cellular metabolism, and oxidative stress in primary fibroblast cells of male and female rats.
Jimenez AG, Winward JD, Smith DM, Ragan CM. Jimenez AG, et al. Physiol Rep. 2018 May;6(9):e13615. doi: 10.14814/phy2.13615. Physiol Rep. 2018. PMID: 29745454 Free PMC article. - Distinct retinal pathways drive spatial orientation behaviors in zebrafish navigation.
Burgess HA, Schoch H, Granato M. Burgess HA, et al. Curr Biol. 2010 Feb 23;20(4):381-6. doi: 10.1016/j.cub.2010.01.022. Epub 2010 Feb 11. Curr Biol. 2010. PMID: 20153194 Free PMC article. - Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model.
Karlsson L, Hiemke C, Carlsson B, Josefsson M, Ahlner J, Bengtsson F, Schmitt U, Kugelberg FC. Karlsson L, et al. Psychopharmacology (Berl). 2011 May;215(2):367-77. doi: 10.1007/s00213-010-2148-5. Epub 2010 Dec 30. Psychopharmacology (Berl). 2011. PMID: 21191569 - Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments.
Balu DT. Balu DT. Exp Clin Psychopharmacol. 2010 Feb;18(1):71-7. doi: 10.1037/a0017295. Exp Clin Psychopharmacol. 2010. PMID: 20158296 Free PMC article. - Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability.
Jochems J, Boulden J, Lee BG, Blendy JA, Jarpe M, Mazitschek R, Van Duzer JH, Jones S, Berton O. Jochems J, et al. Neuropsychopharmacology. 2014 Jan;39(2):389-400. doi: 10.1038/npp.2013.207. Epub 2013 Aug 19. Neuropsychopharmacology. 2014. PMID: 23954848 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical