Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study - PubMed (original) (raw)
. 2002 Mar 2;359(9308):747-52.
doi: 10.1016/S0140-6736(02)07876-5.
Thomas V Perneger, Jacqueline Zittoun, Hélène Bellet, Jean-Christophe Gris, Jean-Pierre Daurès, Jean-François Schved, Eric Mercier, Jean-Pierre Laroche, Michel Dauzat, Henri Bounameaux, Charles Janbon, Philippe de Moerloose
Affiliations
- PMID: 11888585
- DOI: 10.1016/S0140-6736(02)07876-5
Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study
Isabelle Quéré et al. Lancet. 2002.
Abstract
Background: Moderate hyperhomocysteinaemia is a risk factor for venous thromboembolism. We do not know whether this risk depends on homocysteine itself or on components of the homocysteine remethylation pathway, such as methylfolate. We did a case-control study to analyse the relation between the major components of the homocysteine remethylation pathway and risk of venous thromboembolism.
Methods: We measured concentrations of homocysteine, methionine, and folate in plasma, total folate and methylfolate in red-blood cells, and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype and other known risk factors for venous thromboembolic disease in 243 patients with deep vein thrombosis or pulmonary embolism and controls matched for sex and age.
Findings: Concentrations in plasma of homocysteine differed significantly between cases and controls. We noted a strong concentration-dependent association between concentrations of methylfolate in red-blood cells and risk of venous thromboembolism. The adjusted conditional odds ratio ranged from 1.0 for methylfolate 249 microg/L or greater to 7.1 (3.2-15.8) for methylfolate 141 microg/L or less. Methionine concentrations below the median were also independently associated with raised risk of venous thromboembolic disease, as were established risk factors such as high body-mass index, history of cancer, family history of thromboembolism, oral contraceptive use, and factor V Leiden mutation. Furthermore, the association between concentrations of methylfolate in red-blood cells and risk of thromboembolism varied according to MTHFR C677T genotype.
Interpretation: Measurement of methylfolate concentrations in red-blood cells might help to identify people at risk of venous thromboembolism.
Comment in
- Measurement of red blood cell methylfolate.
Lucock M, Yates Z. Lucock M, et al. Lancet. 2002 Sep 28;360(9338):1021-2; author reply 1022. doi: 10.1016/S0140-6736(02)11105-6. Lancet. 2002. PMID: 12383688 No abstract available.
Similar articles
- Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).
Tsai AW, Cushman M, Tsai MY, Heckbert SR, Rosamond WD, Aleksic N, Yanez ND, Psaty BM, Folsom AR. Tsai AW, et al. Am J Hematol. 2003 Mar;72(3):192-200. doi: 10.1002/ajh.10287. Am J Hematol. 2003. PMID: 12605391 - The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis.
Koch HG, Nabel P, Junker R, Auberger K, Schobess R, Homberger A, Linnebank M, Nowak-Göttl U. Koch HG, et al. Eur J Pediatr. 1999 Dec;158 Suppl 3:S113-6. doi: 10.1007/pl00014332. Eur J Pediatr. 1999. PMID: 10650848 - Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism.
De Stefano V, Casorelli I, Rossi E, Zappacosta B, Leone G. De Stefano V, et al. Semin Thromb Hemost. 2000;26(3):305-11. doi: 10.1055/s-2000-8473. Semin Thromb Hemost. 2000. PMID: 11011848 Review.
Cited by
- Case series of retinal vein occlusions showing early recovery using oral l-methylfolate.
Baker S, Baker D, Baker R, Brown CJ. Baker S, et al. Ther Adv Ophthalmol. 2024 Apr 15;16:25158414241240687. doi: 10.1177/25158414241240687. eCollection 2024 Jan-Dec. Ther Adv Ophthalmol. 2024. PMID: 38628356 Free PMC article. - The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study.
Cao Y, Yao T, Chen H, Liu H, Li C, Wang D, Wang Y, Qiu F, Huang H. Cao Y, et al. Transl Cancer Res. 2023 Jan 30;12(1):125-134. doi: 10.21037/tcr-22-2839. Epub 2023 Jan 13. Transl Cancer Res. 2023. PMID: 36760381 Free PMC article. - Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Raghubeer S, Matsha TE. Raghubeer S, et al. Nutrients. 2021 Dec 20;13(12):4562. doi: 10.3390/nu13124562. Nutrients. 2021. PMID: 34960114 Free PMC article. Review. - Recreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment.
Xiang Y, Li L, Ma X, Li S, Xue Y, Yan P, Chen M, Wu J. Xiang Y, et al. Neurotox Res. 2021 Jun;39(3):975-985. doi: 10.1007/s12640-021-00352-y. Epub 2021 Mar 26. Neurotox Res. 2021. PMID: 33770366 Review. - Folate levels in hepatocellular carcinoma patients with portal vein thrombosis.
Malaguarnera G, Catania VE, Latteri S, Borzì AM, Bertino G, Madeddu R, Drago F, Malaguarnera M. Malaguarnera G, et al. BMC Gastroenterol. 2020 Nov 10;20(1):375. doi: 10.1186/s12876-020-01525-3. BMC Gastroenterol. 2020. PMID: 33172390 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical