Imaging hippocampal function across the human life span: is memory decline normal or not? - PubMed (original) (raw)
Imaging hippocampal function across the human life span: is memory decline normal or not?
Scott A Small et al. Ann Neurol. 2002 Mar.
Abstract
Memory function commonly declines in later life. Whether memory decline represents a disease process or whether it is part of normal aging remains unknown. Here we answer this question by assessing the function of multiple subregions that make up the hippocampal circuit across the human life span. A newly developed MRI approach--designed to detect functional changes in individual hippocampal subregions--was used to assess the hippocampal circuit in 70 subjects between 20 and 88 years of age. Using strict parametric criteria, analysis revealed that function in two hippocampal subregions--the subiculum and the dentate gyrus--decline normally with age. In contrast, function in the entorhinal cortex declines pathologically. Single-subject analysis revealed that hippocampal dysfunction, found in 60% of elders was selectively correlated with memory decline. These results show that memory decline is caused by different mechanisms and suggests how memory decline should be approached clinically.
Comment in
- Memory decline: the boundary between aging and age-related disease.
Albert MS. Albert MS. Ann Neurol. 2002 Mar;51(3):282-4. Ann Neurol. 2002. PMID: 11891821 Review. No abstract available. - Concerns with the use of T2* signal intensity to differentiate hippocampal subregions.
Darby DG, Tress BM. Darby DG, et al. Ann Neurol. 2002 Oct;52(4):525-6; author reply 526. doi: 10.1002/ana.10345. Ann Neurol. 2002. PMID: 12325089 No abstract available.
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