RNAi: nature abhors a double-strand - PubMed (original) (raw)

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RNAi: nature abhors a double-strand

György Hutvágner et al. Curr Opin Genet Dev. 2002 Apr.

Abstract

In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation of the double-stranded RNA into small RNAs that then guide a protein nuclease to destroy their mRNA targets.

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