Roles of TGF-beta in hepatic fibrosis - PubMed (original) (raw)

Review

doi: 10.2741/A812.

Affiliations

• PMID: 11897555
• DOI: 10.2741/A812

Review

Roles of TGF-beta in hepatic fibrosis

Axel M Gressner et al. Front Biosci. 2002.

Abstract

TGF-beta has multiple profibrogenic but also anti-inflammatory and immunosuppressive effects. The balance of these actions is required for maintaining tissue homeostasis and an aberrant expression of TGF-beta is involved in a number of disease processes in the liver. In addition to its fibrogenic action leading to transdifferentiation of hepatic stellate cells into myofibroblasts, TGF-beta is also an important negative regulator of proliferation and an inducer of apoptosis. The major portion of TGF-beta is secreted as part of an inactive complex and the details of the activation process in liver have not yet been elucidated. The initially striking simplicity of the core TGF-beta/Smad signaling pathways is rapidly giving way to a much more complex view of intracellular signal transduction mechanisms and recent work has demonstrated the importance of cross-talk among different signaling pathways to either specify, enhance, or inhibit TGF-beta responses. The ubiquitous pathophysiologic relevance of TGF-beta suggests its measurement in blood as a diagnostic tool. Other strategies aim at inhibition of TGF-beta1 function or synthesis as a primary target for the development of antifibrotic strategies and recent advances in cell biology have opened several ways to approach the inhibition of TGF-beta action.

PubMed Disclaimer

Similar articles

• Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling.
  Xiang D, Zou J, Zhu X, Chen X, Luo J, Kong L, Zhang H. Xiang D, et al. Phytomedicine. 2020 Nov;78:153294. doi: 10.1016/j.phymed.2020.153294. Epub 2020 Jul 28. Phytomedicine. 2020. PMID: 32771890
• Liuweiwuling tablets attenuate BDL-induced hepatic fibrosis via modulation of TGF-β/Smad and NF-κB signaling pathways.
  Liu H, Dong F, Li G, Niu M, Zhang C, Han Y, He L, Yin P, Wang B, Sang X, Li R, Wang J, Bai Z, Xiao X. Liu H, et al. J Ethnopharmacol. 2018 Jan 10;210:232-241. doi: 10.1016/j.jep.2017.08.029. Epub 2017 Aug 31. J Ethnopharmacol. 2018. PMID: 28864168
• Anti-TGF-beta strategies for the treatment of chronic liver disease.
  Breitkopf K, Haas S, Wiercinska E, Singer MV, Dooley S. Breitkopf K, et al. Alcohol Clin Exp Res. 2005 Nov;29(11 Suppl):121S-131S. doi: 10.1097/01.alc.0000189284.98684.22. Alcohol Clin Exp Res. 2005. PMID: 16344596 Review.
• Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets.
  Gressner AM, Weiskirchen R. Gressner AM, et al. J Cell Mol Med. 2006 Jan-Mar;10(1):76-99. doi: 10.1111/j.1582-4934.2006.tb00292.x. J Cell Mol Med. 2006. PMID: 16563223 Free PMC article. Review.

Cited by

• Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview.
  Banerjee A, Mukherjee S, Maji BK. Banerjee A, et al. Toxicol Rep. 2021 Apr 29;8:938-961. doi: 10.1016/j.toxrep.2021.04.009. eCollection 2021. Toxicol Rep. 2021. PMID: 34026558 Free PMC article. Review.
• Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.
  Atorrasagasti C, Peixoto E, Aquino JB, Kippes N, Malvicini M, Alaniz L, Garcia M, Piccioni F, Fiore EJ, Bayo J, Bataller R, Guruceaga E, Corrales F, Podhajcer O, Mazzolini G. Atorrasagasti C, et al. PLoS One. 2013;8(2):e54962. doi: 10.1371/journal.pone.0054962. Epub 2013 Feb 11. PLoS One. 2013. PMID: 23408952 Free PMC article.
• Semaphorin 7A contributes to TGF-β-mediated liver fibrogenesis.
  De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Millán C, Brenner DA, Vivarelli M, Mocchegiani F, Marzioni M, Benedetti A, Svegliati-Baroni G. De Minicis S, et al. Am J Pathol. 2013 Sep;183(3):820-30. doi: 10.1016/j.ajpath.2013.05.030. Epub 2013 Jul 11. Am J Pathol. 2013. PMID: 23850082 Free PMC article.
• Glutathione synthesis.
  Lu SC. Lu SC. Biochim Biophys Acta. 2013 May;1830(5):3143-53. doi: 10.1016/j.bbagen.2012.09.008. Epub 2012 Sep 17. Biochim Biophys Acta. 2013. PMID: 22995213 Free PMC article. Review.
• The anti-fibrotic effect of bone morphogenic protein-7(BMP-7) on liver fibrosis.
  Zhong L, Wang X, Wang S, Yang L, Gao H, Yang C. Zhong L, et al. Int J Med Sci. 2013;10(4):441-50. doi: 10.7150/ijms.5765. Epub 2013 Mar 2. Int J Med Sci. 2013. PMID: 23471555 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal