Chromosome translocations: dangerous liaisons revisited - PubMed (original) (raw)

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Chromosome translocations: dangerous liaisons revisited

J D Rowley. Nat Rev Cancer. 2001 Dec.

Abstract

Although it has been clear for more than a century that the chromosomes in human tumour cells are often wildly abnormal, there has been controversy as to whether these changes are primary events or are merely secondary epiphenomena that reflect the genomic instability of these cells. The prevailing view for most of this period was that chromosome changes were secondary events. What happened to change this view?

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