Actin' up: RhoB in cancer and apoptosis - PubMed (original) (raw)

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Actin' up: RhoB in cancer and apoptosis

G C Prendergast. Nat Rev Cancer. 2001 Nov.

Abstract

RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.

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