Natural killer cells, viruses and cancer - PubMed (original) (raw)

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Natural killer cells, viruses and cancer

A Cerwenka et al. Nat Rev Immunol. 2001 Oct.

Abstract

Natural killer cells are innate immune cells that control certain microbial infections and tumours. The function of natural killer cells is regulated by a balance between signals transmitted by activating receptors, which recognize ligands on tumours and virus-infected cells, and inhibitory receptors specific for major histocompatibility complex class I molecules. Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence.

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