Cross-presentation in viral immunity and self-tolerance - PubMed (original) (raw)
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Cross-presentation in viral immunity and self-tolerance
W R Heath et al. Nat Rev Immunol. 2001 Nov.
Abstract
T lymphocytes recognize peptide antigens presented by class I and class II molecules encoded by the major histocompatibility complex (MHC). Classical antigen-presentation studies showed that MHC class I molecules present peptides derived from proteins synthesized within the cell, whereas MHC class II molecules present exogenous proteins captured from the environment. Emerging evidence indicates, however, that dendritic cells have a specialized capacity to process exogenous antigens into the MHC class I pathway. This function, known as cross-presentation, provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self.
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