From T to B and back again: positive feedback in systemic autoimmune disease - PubMed (original) (raw)
Review
From T to B and back again: positive feedback in systemic autoimmune disease
M J Shlomchik et al. Nat Rev Immunol. 2001 Nov.
Abstract
Systemic lupus erythematosus, a prototypical systemic autoimmune disease, is the result of a series of interactions within the immune system that ultimately lead to the loss of self-tolerance to nuclear autoantigens. Here, we present an integrated model that explains how self-tolerance is initially lost and how the loss of tolerance is then amplified and maintained as a chronic autoimmune state. Key to this model are the self-reinforcing interactions of T and B cells, which we suggest lead to perpetuation of autoimmunity as well as its spread to multiple autoantigen targets.
Similar articles
- Breakdown of self-tolerance and the pathogenesis of autoimmunity.
Ring GH, Lakkis FG. Ring GH, et al. Semin Nephrol. 1999 Jan;19(1):25-33. Semin Nephrol. 1999. PMID: 9952278 Review. - Mouse models of systemic lupus erythematosus reveal a complex pathogenesis.
Rottman JB, Willis CR. Rottman JB, et al. Vet Pathol. 2010 Jul;47(4):664-76. doi: 10.1177/0300985810370005. Epub 2010 May 6. Vet Pathol. 2010. PMID: 20448279 Review. - Diseases of autoimmunity.
Dixon FJ. Dixon FJ. Natl Cancer Inst Monogr. 1982;60:181-92. Natl Cancer Inst Monogr. 1982. PMID: 6214718 No abstract available. - B cell tolerance to self in systemic autoimmunity.
Zouali M. Zouali M. Arch Immunol Ther Exp (Warsz). 2001;49(5):361-5. Arch Immunol Ther Exp (Warsz). 2001. PMID: 11798134 Review. - [Apoptosis in the regulation of immune processes and in the pathogenesis of autoimmune diseases].
Müzes G, Igaz P. Müzes G, et al. Orv Hetil. 1997 May 25;138(21):1315-20. Orv Hetil. 1997. PMID: 9254350 Review. Hungarian.
Cited by
- miR-132-3p downregulates FOXO1 in CD4**+** T cells and is associated with disease manifestations in patients with lupus.
Qin H, Chen S, Liu X, Liang J, Wu H, Zhu X. Qin H, et al. J Int Med Res. 2024 Oct;52(10):3000605241286762. doi: 10.1177/03000605241286762. J Int Med Res. 2024. PMID: 39429035 Free PMC article. - Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review).
Niu Q, Hao J, Li Z, Zhang H. Niu Q, et al. Mol Med Rep. 2024 Dec;30(6):215. doi: 10.3892/mmr.2024.13339. Epub 2024 Sep 27. Mol Med Rep. 2024. PMID: 39370806 Free PMC article. Review. - Wilson's Disease-Crossroads of Genetics, Inflammation and Immunity/Autoimmunity: Clinical and Molecular Issues.
Gromadzka G, Czerwińska J, Krzemińska E, Przybyłkowski A, Litwin T. Gromadzka G, et al. Int J Mol Sci. 2024 Aug 20;25(16):9034. doi: 10.3390/ijms25169034. Int J Mol Sci. 2024. PMID: 39201720 Free PMC article. Review. - Targeting Bruton's tyrosine kinase (BTK) as a signaling pathway in immune-mediated diseases: from molecular mechanisms to leading treatments.
Tavakoli GM, Yazdanpanah N, Rezaei N. Tavakoli GM, et al. Adv Rheumatol. 2024 Aug 21;64(1):61. doi: 10.1186/s42358-024-00401-y. Adv Rheumatol. 2024. PMID: 39169436 Review. - The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis.
Li Y, Vyas SP, Mehta I, Asada N, Dey I, Taylor TC, Bechara R, Amatya N, Aggor FEY, Coleman BM, Li DD, Yamamoto K, Ezenwa O, Sun Y, Sterneck E, McManus CJ, Panzer U, Biswas PS, Savan R, Das J, Gaffen SL. Li Y, et al. J Exp Med. 2024 Sep 2;221(9):e20240656. doi: 10.1084/jem.20240656. Epub 2024 Jul 26. J Exp Med. 2024. PMID: 39058386
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical