The RNA polymerase II machinery: structure illuminates function - PubMed (original) (raw)

Review

. 2002 Feb 22;108(4):453-63.

doi: 10.1016/s0092-8674(02)00646-3.

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Review

The RNA polymerase II machinery: structure illuminates function

Nancy A Woychik et al. Cell. 2002.

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Abstract

Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.

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