The RNA polymerase II machinery: structure illuminates function - PubMed (original) (raw)
Review
. 2002 Feb 22;108(4):453-63.
doi: 10.1016/s0092-8674(02)00646-3.
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- PMID: 11909517
- DOI: 10.1016/s0092-8674(02)00646-3
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Review
The RNA polymerase II machinery: structure illuminates function
Nancy A Woychik et al. Cell. 2002.
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Abstract
Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.
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