Integrating mRNA processing with transcription - PubMed (original) (raw)
Review
. 2002 Feb 22;108(4):501-12.
doi: 10.1016/s0092-8674(02)00617-7.
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- PMID: 11909521
- DOI: 10.1016/s0092-8674(02)00617-7
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Review
Integrating mRNA processing with transcription
Nick J Proudfoot et al. Cell. 2002.
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Abstract
The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.
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