The basal ganglia and disorders of movement: pathophysiological mechanisms - PubMed (original) (raw)

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The basal ganglia and disorders of movement: pathophysiological mechanisms

José A Obeso et al. News Physiol Sci. 2002 Apr.

Abstract

The basal ganglia are part of a neuronal network organized in parallel circuits. The "motor circuit" is most relevant to the pathophysiology of movement. Abnormal increment or reduction in the inhibitory output activity of basal ganglia give rise, respectively, to poverty and slowness of movement (i.e., Parkinson's disease) or dyskinesias.

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