Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish - PubMed (original) (raw)

. 2002 Mar;205(Pt 6):711-8.

doi: 10.1242/jeb.205.6.711.

Affiliations

• PMID: 11914381
• DOI: 10.1242/jeb.205.6.711

Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish

Daisuke Uchida et al. J Exp Biol. 2002 Mar.

Abstract

Large numbers of apoptotic early diplotene oocytes were observed during the transition from ovary-like undifferentiated gonadal tissue to testes during sex differentiation in presumptive males of the zebrafish (Danio rerio). The percentage of terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labelling (TUNEL)-positive apoptotic oocytes in the gonads of presumptive males was approximately eight- to 12-fold higher than in genetic all-females. By 29 days post-hatching, all oocytes had disappeared from the gonads of presumptive males. In these males, we also observed apoptotic somatic cells in the ovarian cavity between 23 and 35 days post-hatching. Therefore, the disappearance of oocytes and the decomposition of the ovarian cavity caused by apoptosis during sex differentiation were male-specific events. In genetic all-females, apoptosis in a proportion of early diplotene oocytes was found in the undifferentiated gonads at 15-19 days post-hatching, probably as a result of programmed oocyte loss during ovarian development. These findings suggest that oocyte apoptosis is the mechanism of testicular and ovarian differentiation in zebrafish.

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