Reorganization of human cortical maps caused by inherited photoreceptor abnormalities - PubMed (original) (raw)
Reorganization of human cortical maps caused by inherited photoreceptor abnormalities
Heidi A Baseler et al. Nat Neurosci. 2002 Apr.
Abstract
We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.
Similar articles
- Cortical Visual Mapping following Ocular Gene Augmentation Therapy for Achromatopsia.
McKyton A, Averbukh E, Marks Ohana D, Levin N, Banin E. McKyton A, et al. J Neurosci. 2021 Sep 1;41(35):7363-7371. doi: 10.1523/JNEUROSCI.3222-20.2021. Epub 2021 Aug 4. J Neurosci. 2021. PMID: 34349002 Free PMC article. - CNGB3 achromatopsia with progressive loss of residual cone function and impaired rod-mediated function.
Khan NW, Wissinger B, Kohl S, Sieving PA. Khan NW, et al. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3864-71. doi: 10.1167/iovs.06-1521. Invest Ophthalmol Vis Sci. 2007. PMID: 17652762 - Blindsight mediated by an S-cone-independent collicular pathway: an fMRI study in hemispherectomized subjects.
Leh SE, Ptito A, Schönwiesner M, Chakravarty MM, Mullen KT. Leh SE, et al. J Cogn Neurosci. 2010 Apr;22(4):670-82. doi: 10.1162/jocn.2009.21217. J Cogn Neurosci. 2010. PMID: 19309296 - [Physiology and pathology of visual information processing].
Kitahara K. Kitahara K. Nippon Ganka Gakkai Zasshi. 2007 Mar;111(3):160-91; discussion 192. Nippon Ganka Gakkai Zasshi. 2007. PMID: 17402561 Review. Japanese. - Distribution and specificity of S-cone ("blue cone") signals in subcortical visual pathways.
Martin PR, Lee BB. Martin PR, et al. Vis Neurosci. 2014 Mar;31(2):177-87. doi: 10.1017/S0952523813000631. Epub 2014 Feb 20. Vis Neurosci. 2014. PMID: 24555883 Review.
Cited by
- Longitudinal Assessment of OCT-Based Measures of Foveal Cone Structure in Achromatopsia.
Grissim G, Walesa A, Follett HM, Higgins BP, Goetschel K, Heitkotter H, Carroll J. Grissim G, et al. Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):16. doi: 10.1167/iovs.65.4.16. Invest Ophthalmol Vis Sci. 2024. PMID: 38587442 Free PMC article. - Cortical field maps across human sensory cortex.
Brewer AA, Barton B. Brewer AA, et al. Front Comput Neurosci. 2023 Dec 15;17:1232005. doi: 10.3389/fncom.2023.1232005. eCollection 2023. Front Comput Neurosci. 2023. PMID: 38164408 Free PMC article. Review. - Achromatopsia-Visual Cortex Stability and Plasticity in the Absence of Functional Cones.
Molz B, Herbik A, Baseler HA, de Best P, Raz N, Gouws A, Ahmadi K, Lowndes R, McLean RJ, Gottlob I, Kohl S, Choritz L, Maguire J, Kanowski M, Käsmann-Kellner B, Wieland I, Banin E, Levin N, Morland AB, Hoffmann MB. Molz B, et al. Invest Ophthalmol Vis Sci. 2023 Oct 3;64(13):23. doi: 10.1167/iovs.64.13.23. Invest Ophthalmol Vis Sci. 2023. PMID: 37847226 Free PMC article. - [Achromatopsia : Clinical aspects, diagnostics, genes, brain and quality of life].
Käsmann-Kellner B, Hoffmann MB. Käsmann-Kellner B, et al. Ophthalmologie. 2023 Sep;120(9):975-986. doi: 10.1007/s00347-023-01904-7. Epub 2023 Aug 28. Ophthalmologie. 2023. PMID: 37638972 German. - Neuroimaging in Leber Hereditary Optic Neuropathy: State-of-the-art and future prospects.
Chow-Wing-Bom HT, Callaghan MF, Wang J, Wei S, Dick F, Yu-Wai-Man P, Dekker TM. Chow-Wing-Bom HT, et al. Neuroimage Clin. 2022;36:103240. doi: 10.1016/j.nicl.2022.103240. Epub 2022 Oct 25. Neuroimage Clin. 2022. PMID: 36510411 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical