Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences - PubMed (original) (raw)
Review
. 2002 Apr 15;34(8):1108-14.
doi: 10.1086/339547. Epub 2002 Mar 15.
Affiliations
- PMID: 11915000
- DOI: 10.1086/339547
Review
Human immunodeficiency virus superinfection and recombination: current state of knowledge and potential clinical consequences
Jason T Blackard et al. Clin Infect Dis. 2002.
Abstract
Superinfection with multiple strains or subtypes of the human and simian immunodeficiency viruses has been documented. Recent increases in the prevalences of both unprotected anal intercourse and sexually transmitted diseases among men who have sex with men indicate that these men continue to practice unsafe sex and, therefore, are at risk for superinfection with the human immunodeficiency virus (HIV). Recurrent exposure to HIV among seropositive individuals who engage in high-risk behaviors can have serious consequences, because superinfection is a necessary first step for viral recombination to occur. Recombination may produce more virulent viruses, drug-resistant viruses, or viruses with altered cell tropism. Additionally, recombinant viruses and superinfection can accelerate disease progression and increase the likelihood of sexual transmission by increasing virus load in the blood and genital tract. The extent of superinfection and recombination in persons living with HIV is unknown. The implications of HIV superinfection and the generation of recombinant viruses are discussed.
Similar articles
- HIV-1 co-infection, superinfection and recombination.
Steain MC, Wang B, Dwyer DE, Saksena NK. Steain MC, et al. Sex Health. 2004;1(4):239-50. doi: 10.1071/sh04024. Sex Health. 2004. PMID: 16335754 Review. - Sexually transmitted hepatitis C virus superinfection in HIV/hepatitis C virus co-infected men who have sex with men.
Ghosn J, Thibault V, Delaugerre C, Fontaine H, Lortholary O, Rouzioux C, Pol S, Chaix ML. Ghosn J, et al. AIDS. 2008 Mar 12;22(5):658-61. doi: 10.1097/QAD.0b013e3282f4e86f. AIDS. 2008. PMID: 18317011 - HIV-1 intra-subtype superinfection rates: estimates using a structured coalescent with recombination.
Taylor JE, Korber BT. Taylor JE, et al. Infect Genet Evol. 2005 Jan;5(1):85-95. doi: 10.1016/j.meegid.2004.07.001. Infect Genet Evol. 2005. PMID: 15567142 - Patterns of sexual behaviour and reported symptoms of STI/RTIs among young people in Croatia--implications for interventions' planning.
Bozicević I, Stulhofer A, Ajduković D, Kufrin K. Bozicević I, et al. Coll Antropol. 2006 Dec;30 Suppl 2:63-70. Coll Antropol. 2006. PMID: 17508477 - [HIV superinfection: myth or reality?].
Vernazza PL, Bernasconi E, Hirschel B. Vernazza PL, et al. Schweiz Med Wochenschr. 2000 Aug 8;130(31-32):1101-4. Schweiz Med Wochenschr. 2000. PMID: 11008302 Review. German.
Cited by
- Towards Understanding and Identification of Human Viral Co-Infections.
Wu H, Zhou HY, Zheng H, Wu A. Wu H, et al. Viruses. 2024 Apr 25;16(5):673. doi: 10.3390/v16050673. Viruses. 2024. PMID: 38793555 Free PMC article. Review. - Clinical and molecular aspects of human pegiviruses in the interaction host and infectious agent.
Samadi M, Salimi V, Haghshenas MR, Miri SM, Mohebbi SR, Ghaemi A. Samadi M, et al. Virol J. 2022 Mar 9;19(1):41. doi: 10.1186/s12985-022-01769-3. Virol J. 2022. PMID: 35264187 Free PMC article. Review. - The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction Perspective.
Gómez SA, Rojas-Valencia N, Gómez S, Cappelli C, Restrepo A. Gómez SA, et al. Chembiochem. 2022 Apr 5;23(7):e202100393. doi: 10.1002/cbic.202100393. Epub 2021 Oct 8. Chembiochem. 2022. PMID: 34529328 Free PMC article. - No need to beat around the bushmeat-The role of wildlife trade and conservation initiatives in the emergence of zoonotic diseases.
Hilderink MH, de Winter II. Hilderink MH, et al. Heliyon. 2021 Jul 30;7(7):e07692. doi: 10.1016/j.heliyon.2021.e07692. eCollection 2021 Jul. Heliyon. 2021. PMID: 34386637 Free PMC article. Review. - The variants question: What is the problem?
Zella D, Giovanetti M, Benedetti F, Unali F, Spoto S, Guarino M, Angeletti S, Ciccozzi M. Zella D, et al. J Med Virol. 2021 Dec;93(12):6479-6485. doi: 10.1002/jmv.27196. Epub 2021 Jul 28. J Med Virol. 2021. PMID: 34255352 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical