C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies - PubMed (original) (raw)
C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies
Vijaya Vegesna et al. Leuk Res. 2002 May.
Abstract
Mutations of transcription factors are associated with the pathogenesis of cancer. Genomic DNA from 381 cancers and cell lines representing leukemias, lymphomas and a variety of solid tumors were examined for mutations of genes coding for the C/EBP-beta, C/EBP-alpha, PU.1, and AML1 transcription factors using single strand conformation polymorphism (SSCP) and direct DNA sequencing. Mutation of C/EBP-beta (a chronic myelogenous leukemia cell line, Kcl22) and C/EBP-delta (a Burkitt's lymphoma cell line, Raji) were found. Interestingly, the sample with a C/EBP-beta alterations had two missense (P236L and G252A) and two silent mutations in a highly conserved region of the gene. The C/EBP-delta alteration in Raji was a missense mutation (A177G). These findings suggest that mutations of the C/EBP-beta, C/EBP-delta, PU.1, and AML1 rarely contribute to the development of hematopoietic or solid cancers.
Comment in
- Mutations in human cancer: how close should we look?
Cammenga J, Nimer SD. Cammenga J, et al. Leuk Res. 2002 May;26(5):459-60. doi: 10.1016/s0145-2126(01)00174-6. Leuk Res. 2002. PMID: 11916519 No abstract available.
Similar articles
- Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.
Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP. Gombart AF, et al. Blood. 2003 Apr 15;101(8):3265-73. doi: 10.1182/blood-2002-04-1039. Epub 2002 Dec 19. Blood. 2003. PMID: 12515729 - Mutations in human cancer: how close should we look?
Cammenga J, Nimer SD. Cammenga J, et al. Leuk Res. 2002 May;26(5):459-60. doi: 10.1016/s0145-2126(01)00174-6. Leuk Res. 2002. PMID: 11916519 No abstract available. - CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.
Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, Hiebert SW, Tenen DG. Zhang DE, et al. Mol Cell Biol. 1996 Mar;16(3):1231-40. doi: 10.1128/MCB.16.3.1231. Mol Cell Biol. 1996. PMID: 8622667 Free PMC article. - Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters.
Zhang DE, Hohaus S, Voso MT, Chen HM, Smith LT, Hetherington CJ, Tenen DG. Zhang DE, et al. Curr Top Microbiol Immunol. 1996;211:137-47. doi: 10.1007/978-3-642-85232-9_14. Curr Top Microbiol Immunol. 1996. PMID: 8585944 Review. - Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome.
Imai O, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa S, Chiba S, Mitani K, Hirai H. Imai O, et al. Leuk Lymphoma. 2002 Mar;43(3):617-21. doi: 10.1080/10428190290012155. Leuk Lymphoma. 2002. PMID: 12002768 Review.
Cited by
- Emerging functions of C/EBPβ in breast cancer.
Matherne MG, Phillips ES, Embrey SJ, Burke CM, Machado HL. Matherne MG, et al. Front Oncol. 2023 Jan 25;13:1111522. doi: 10.3389/fonc.2023.1111522. eCollection 2023. Front Oncol. 2023. PMID: 36761942 Free PMC article. Review. - Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing.
Johansson P, Klein-Hitpass L, Budeus B, Kuhn M, Lauber C, Seifert M, Roeder I, Pförtner R, Stuschke M, Dührsen U, Eckstein A, Dürig J, Küppers R. Johansson P, et al. Cancers (Basel). 2020 Apr 17;12(4):986. doi: 10.3390/cancers12040986. Cancers (Basel). 2020. PMID: 32316399 Free PMC article. - The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G. Lavallée VP, et al. Nat Genet. 2015 Sep;47(9):1030-7. doi: 10.1038/ng.3371. Epub 2015 Aug 3. Nat Genet. 2015. PMID: 26237430 - Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.
Sive JI, Basilico S, Hannah R, Kinston SJ, Calero-Nieto FJ, Göttgens B. Sive JI, et al. Leukemia. 2016 Jan;30(1):14-23. doi: 10.1038/leu.2015.172. Epub 2015 Jul 1. Leukemia. 2016. PMID: 26126967 Free PMC article. - Non-steady-state hematopoiesis regulated by the C/EBPβ transcription factor.
Hirai H, Yokota A, Tamura A, Sato A, Maekawa T. Hirai H, et al. Cancer Sci. 2015 Jul;106(7):797-802. doi: 10.1111/cas.12690. Epub 2015 Jun 1. Cancer Sci. 2015. PMID: 25940801 Free PMC article.