Hematologic and blood biochemical variables of captive chimpanzees: cross-sectional and longitudinal analyses - PubMed (original) (raw)
Affiliations
- PMID: 11926304
Hematologic and blood biochemical variables of captive chimpanzees: cross-sectional and longitudinal analyses
J G Herndon et al. Comp Med. 2001 Feb.
Abstract
Hematologic and blood biochemical variables are of great importance in medical and veterinary practice. In addition, these analytes may have significance as potential biomarkers of aging. Previous reports on normative values of these variables in the chimpanzees are based on cross-sectional studies that did not include individuals of advanced age. To address this omission, we performed cross-sectional and longitudinal analyses of hematologic and blood biochemical data collected from chimpanzees over a 9-year period. One-hundred forty-six females and 106 males of ages representing the entire life span of the species were studied. We derived normative cross-sectional values of 14 commonly measured hematologic and 20 blood biochemical variables, which should provide a useful reference for clinical blood studies in chimpanzees. In addition, we found in a cross-sectional regression analysis of our data that most analytes varied significantly between males and females, and that they varied markedly with age. Most variables had year-to-year consistency within the same individuals, as indicated by statistically significant intra-year correlation coefficients. Finally, we performed a longitudinal analysis of the analytes in chimpanzees by calculating the slopes and intercepts of the best-fitting trend line for each individual. The resulting slopes were analyzed by sex and by decade of age of subjects to determine whether trends were consistent. Consistent trends detected in the longitudinal analysis were usually restricted to the first decade of life, and thus represented maturational processes. The overall lack of within-animal trends covering all or most of the period from early adulthood through old age in this 9-year study suggests that a longer period of follow-up than used here may be required to document senescence-related changes.
Similar articles
- Hematologic and serum biochemical reference intervals for the chimpanzee (Pan troglodytes) categorized by age and sex.
Ihrig M, Tassinary LG, Bernacky B, Keeling ME. Ihrig M, et al. Comp Med. 2001 Feb;51(1):30-7. Comp Med. 2001. PMID: 11926299 - Normal hematologic and serum clinical chemistry values for captive chimpanzees (Pan troglodytes).
Howell S, Hoffman K, Bartel L, Schwandt M, Morris J, Fritz J. Howell S, et al. Comp Med. 2003 Aug;53(4):413-23. Comp Med. 2003. PMID: 14524418 - Effects of aging on hematology and serum clinical chemistry in chimpanzees (Pan troglodytes).
Videan EN, Fritz J, Murphy J. Videan EN, et al. Am J Primatol. 2008 Apr;70(4):327-38. doi: 10.1002/ajp.20494. Am J Primatol. 2008. PMID: 17943981 - Reproductive aging in captive and wild common chimpanzees: factors influencing the rate of follicular depletion.
Atsalis S, Videan E. Atsalis S, et al. Am J Primatol. 2009 Apr;71(4):271-82. doi: 10.1002/ajp.20650. Am J Primatol. 2009. PMID: 19067363 Review. - [WHO growth standards for infants and young children].
de Onis M, Garza C, Onyango AW, Rolland-Cachera MF; le Comité de nutrition de la Société française de pédiatrie. de Onis M, et al. Arch Pediatr. 2009 Jan;16(1):47-53. doi: 10.1016/j.arcped.2008.10.010. Epub 2008 Nov 25. Arch Pediatr. 2009. PMID: 19036567 Review. French.
Cited by
- Age- and sex-based hematological and biochemical parameters for Macaca fascicularis.
Xie L, Xu F, Liu S, Ji Y, Zhou Q, Wu Q, Gong W, Cheng K, Li J, Li L, Fang L, Zhou L, Xie P. Xie L, et al. PLoS One. 2013 Jun 10;8(6):e64892. doi: 10.1371/journal.pone.0064892. Print 2013. PLoS One. 2013. PMID: 23762263 Free PMC article. - Healthy cardiovascular biomarkers across the lifespan in wild-born chimpanzees (Pan troglodytes).
Cole MF, Cantwell A, Rukundo J, Ajarova L, Fernandez-Navarro S, Atencia R, Rosati AG. Cole MF, et al. Philos Trans R Soc Lond B Biol Sci. 2020 Nov 9;375(1811):20190609. doi: 10.1098/rstb.2019.0609. Epub 2020 Sep 21. Philos Trans R Soc Lond B Biol Sci. 2020. PMID: 32951545 Free PMC article. - Hematological and serum biochemical indices in healthy bonnet macaques (Macaca radiata).
Pierre PJ, Sequeira MK, Corcoran CA, Blevins MW, Gee M, Laudenslager ML, Bennett AJ. Pierre PJ, et al. J Med Primatol. 2011 Oct;40(5):287-93. doi: 10.1111/j.1600-0684.2011.00466.x. Epub 2011 Mar 3. J Med Primatol. 2011. PMID: 21366603 Free PMC article. - Lineage-Specific Changes in Biomarkers in Great Apes and Humans.
Ronke C, Dannemann M, Halbwax M, Fischer A, Helmschrodt C, Brügel M, André C, Atencia R, Mugisha L, Scholz M, Ceglarek U, Thiery J, Pääbo S, Prüfer K, Kelso J. Ronke C, et al. PLoS One. 2015 Aug 6;10(8):e0134548. doi: 10.1371/journal.pone.0134548. eCollection 2015. PLoS One. 2015. PMID: 26247603 Free PMC article. - Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees.
Behringer V, Wudy SA, Blum WF, Stevens JM, Remer T, Boesch C, Hohmann G. Behringer V, et al. Front Endocrinol (Lausanne). 2016 Aug 23;7:118. doi: 10.3389/fendo.2016.00118. eCollection 2016. Front Endocrinol (Lausanne). 2016. PMID: 27602019 Free PMC article.