Invasive growth: from development to metastasis - PubMed (original) (raw)
Review
Invasive growth: from development to metastasis
Paolo M Comoglio et al. J Clin Invest. 2002 Apr.
No abstract available
Figures
Figure 1
The invasive growth program under physiological and pathological conditions. In both settings, invasive growth results from analogous biological processes - cell-cell dissociation and migration, cell multiplication, and survival - but the endpoints are different. Normal cells exploit invasive growth to colonize new territories and build polarized three-dimensional structures, thus forming the parenchymal architecture of several organs. Cancer cells implement this program aberrantly to infiltrate the adjacent surroundings and form metastases.
Figure 2
(a) Structural features shared by plexins, semaphorins, and PRGF receptors. Plexins are divided into four subfamilies (A–D) based on sequence similarity, structural features, and tissue distribution. All plexins include a highly conserved cytoplasmic domain (SP domain, green box and oval) and, in the extracellular portion, a sema domain (yellow) and one or more MRS motifs (orange), which are also present in semaphorins and PRGF receptors. Almost 20 semaphorins are known in humans, falling into five subclasses (3 to 7). As an example, a class 4 transmembrane semaphorin is depicted. (b) Protein alignment of an MRS conserved domain. Two or three MRS repeats are found in plexins, whereas only one is present in PRGF receptors and semaphorins. The alignment shows the first MRS motif of human plexin-A1, -A3, -B1, -C1, and -D1, as well as the Drosophila plexin-A and -B, the mouse plexin-A2, and the MRSs from Sema-3F, Sema-4D, and Met. The number and the spacing of cysteine residues (yellow) are conserved.
Comment in
- Dysregulation of Met receptor tyrosine kinase activity in invasive tumors.
Danilkovitch-Miagkova A, Zbar B. Danilkovitch-Miagkova A, et al. J Clin Invest. 2002 Apr;109(7):863-7. doi: 10.1172/JCI15418. J Clin Invest. 2002. PMID: 11927612 Free PMC article. Review. No abstract available.
Comment on
- Dysregulation of Met receptor tyrosine kinase activity in invasive tumors.
Danilkovitch-Miagkova A, Zbar B. Danilkovitch-Miagkova A, et al. J Clin Invest. 2002 Apr;109(7):863-7. doi: 10.1172/JCI15418. J Clin Invest. 2002. PMID: 11927612 Free PMC article. Review. No abstract available.
Similar articles
- Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.
Bagnard D, Vaillant C, Khuth ST, Dufay N, Lohrum M, Puschel AW, Belin MF, Bolz J, Thomasset N. Bagnard D, et al. J Neurosci. 2001 May 15;21(10):3332-41. doi: 10.1523/JNEUROSCI.21-10-03332.2001. J Neurosci. 2001. PMID: 11331362 Free PMC article. - The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.
Weidner KM, Sachs M, Birchmeier W. Weidner KM, et al. J Cell Biol. 1993 Apr;121(1):145-54. doi: 10.1083/jcb.121.1.145. J Cell Biol. 1993. PMID: 8384622 Free PMC article. - Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.
Peace BE, Hughes MJ, Degen SJ, Waltz SE. Peace BE, et al. Oncogene. 2001 Sep 27;20(43):6142-51. doi: 10.1038/sj.onc.1204836. Oncogene. 2001. PMID: 11593422 - Scatter factor and its relationship to hepatocyte growth factor and met.
Rosen EM, Knesel J, Goldberg ID. Rosen EM, et al. Cell Growth Differ. 1991 Nov;2(11):603-7. Cell Growth Differ. 1991. PMID: 1839956 Review. No abstract available. - Interactions between scatter factors and their receptors: hints for therapeutic applications.
Trusolino L, Pugliese L, Comoglio PM. Trusolino L, et al. FASEB J. 1998 Oct;12(13):1267-80. doi: 10.1096/fasebj.12.13.1267. FASEB J. 1998. PMID: 9761771 Review.
Cited by
- Proteomics and Bioinformatics Identify Drug-Resistant-Related Genes with Prognostic Potential in Cholangiocarcinoma.
Kerdkumthong K, Roytrakul S, Songsurin K, Pratummanee K, Runsaeng P, Obchoei S. Kerdkumthong K, et al. Biomolecules. 2024 Aug 8;14(8):969. doi: 10.3390/biom14080969. Biomolecules. 2024. PMID: 39199357 Free PMC article. - Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis.
Lee CC, Yu CJ, Panda SS, Chen KC, Liang KH, Huang WC, Wang YS, Ho PC, Wu HC. Lee CC, et al. J Transl Med. 2023 Aug 5;21(1):530. doi: 10.1186/s12967-023-04390-2. J Transl Med. 2023. PMID: 37543570 Free PMC article. - Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination.
Modica C, Cortese M, Bersani F, Lombardi AM, Napoli F, Righi L, Taulli R, Basilico C, Vigna E. Modica C, et al. Cancers (Basel). 2023 May 13;15(10):2742. doi: 10.3390/cancers15102742. Cancers (Basel). 2023. PMID: 37345079 Free PMC article. - Merestinib monotherapy or in combination for japanese patients with advanced and/or metastatic cancer: A phase 1 study.
Doi T, Yamamoto N, Naito Y, Kuboki Y, Koyama T, Piao Y, Tsujimoto N, Asou H, Inoue K, Kondo S. Doi T, et al. Cancer Med. 2021 Oct;10(19):6579-6589. doi: 10.1002/cam4.4110. Epub 2021 Sep 9. Cancer Med. 2021. PMID: 34499416 Free PMC article. Clinical Trial. - HGF/MET Axis Induces Tumor Secretion of Tenascin-C and Promotes Stromal Rewiring in Pancreatic Cancer.
Modica C, Olivero M, Zuppini F, Milan M, Basilico C, Vigna E. Modica C, et al. Cancers (Basel). 2021 Jul 14;13(14):3519. doi: 10.3390/cancers13143519. Cancers (Basel). 2021. PMID: 34298732 Free PMC article.
References
- Comoglio PM, Boccaccio C. Scatter factors and invasive growth. Semin Cancer Biol. 2001;11:153–165. - PubMed
- Trusolino L, Pugliese L, Comoglio PM. Interactions between scatter factors and their receptors: hints for therapeutic applications. FASEB J. 1998;12:1267–1280. - PubMed
- Matsumoto K, Kataoka H, Date K, Nakamura T. Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. J Biol Chem. 1998;273:22913–22920. - PubMed
- Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell motility. Nature. 1987;327:239–242. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources