Prime movers of synaptic vesicle exocytosis - PubMed (original) (raw)
Review
Prime movers of synaptic vesicle exocytosis
T F J Martin. Neuron. 2002.
Abstract
Chemical synapses contain specialized pre- and postsynaptic structures that underlie rapid synaptic transmission and its modulation. Studies of postsynaptic organization have revealed a network of interacting proteins that enable rapid synaptic responses and their modulation. Recent genetic and electrophysiological studies on two active zone proteins-RIM and Munc13-reveal important roles in priming vesicles for Ca(2+)-triggered fusion and in mediating the regulation of this process. This work sheds new light on how presynaptic structure provides speed and plasticity to synaptic transmission.
Similar articles
- Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.
Zarebidaki F, Camacho M, Brockmann MM, Trimbuch T, Herman MA, Rosenmund C. Zarebidaki F, et al. J Neurosci. 2020 Dec 2;40(49):9372-9385. doi: 10.1523/JNEUROSCI.1922-20.2020. Epub 2020 Nov 2. J Neurosci. 2020. PMID: 33139401 Free PMC article. - The presynaptic active zone.
Südhof TC. Südhof TC. Neuron. 2012 Jul 12;75(1):11-25. doi: 10.1016/j.neuron.2012.06.012. Neuron. 2012. PMID: 22794257 Free PMC article. Review. - Does the fusion pore contribute to synaptic plasticity?
Krupa B, Liu G. Krupa B, et al. Trends Neurosci. 2004 Feb;27(2):62-6. doi: 10.1016/j.tins.2003.11.006. Trends Neurosci. 2004. PMID: 15106637 Review. - Nanoscale Organization of Vesicle Release at Central Synapses.
Gramlich MW, Klyachko VA. Gramlich MW, et al. Trends Neurosci. 2019 Jun;42(6):425-437. doi: 10.1016/j.tins.2019.03.001. Trends Neurosci. 2019. PMID: 31176424 Free PMC article. Review. - Synaptic Vesicle Clusters at Synapses: A Distinct Liquid Phase?
Milovanovic D, De Camilli P. Milovanovic D, et al. Neuron. 2017 Mar 8;93(5):995-1002. doi: 10.1016/j.neuron.2017.02.013. Neuron. 2017. PMID: 28279363 Free PMC article. Review.
Cited by
- RIC-7 promotes neuropeptide secretion.
Hao Y, Hu Z, Sieburth D, Kaplan JM. Hao Y, et al. PLoS Genet. 2012 Jan;8(1):e1002464. doi: 10.1371/journal.pgen.1002464. Epub 2012 Jan 19. PLoS Genet. 2012. PMID: 22275875 Free PMC article. - Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
Wang Z, Liu H, Gu Y, Chapman ER. Wang Z, et al. J Cell Biol. 2011 Dec 26;195(7):1159-70. doi: 10.1083/jcb.201104079. Epub 2011 Dec 19. J Cell Biol. 2011. PMID: 22184197 Free PMC article. - Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.
Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW. Zhu Y, et al. J Physiol. 2008 Apr 1;586(7):1977-92. doi: 10.1113/jphysiol.2007.149310. Epub 2008 Feb 7. J Physiol. 2008. PMID: 18258655 Free PMC article. - Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle.
Yanay C, Morpurgo N, Linial M. Yanay C, et al. Genome Biol. 2008;9(2):R27. doi: 10.1186/gb-2008-9-2-r27. Epub 2008 Feb 7. Genome Biol. 2008. PMID: 18257909 Free PMC article. - Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse.
Hosoi N, Sakaba T, Neher E. Hosoi N, et al. J Neurosci. 2007 Dec 26;27(52):14286-98. doi: 10.1523/JNEUROSCI.4122-07.2007. J Neurosci. 2007. PMID: 18160636 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous