Translation initiation and its deregulation during tumorigenesis - PubMed (original) (raw)
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Translation initiation and its deregulation during tumorigenesis
S J Watkins et al. Br J Cancer. 2002.
Free PMC article
Abstract
Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development. Most bulk protein synthesis is initiated via recognition of the mRNA 5' cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism. However, several key regulators of tumour development are translated by a cap-independent pathway. Here we review eukaryotic translation initiation, its regulation and the ways in which this regulation can break down during tumorigenesis.
Figures
Figure 1
Components of the 48S translation pre-initiation complex. A polyadenylated mRNA (top) is circularised by being bound at its 5′ cap by eIF4E and at its 3′ end by poly(A)-binding protein (PABP). Both of these proteins are in turn bound to the scaffold protein eIF4G, which also provides a link to the 40S ribosomal subunit (bottom). For additional details see text.
References
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