Translation initiation and its deregulation during tumorigenesis - PubMed (original) (raw)

Review

Translation initiation and its deregulation during tumorigenesis

S J Watkins et al. Br J Cancer. 2002.

Free PMC article

Abstract

Regulation of protein synthesis at the level of translation initiation is fundamentally important for the control of cell proliferation under normal physiological conditions. Conversely, misregulation of protein synthesis is emerging as a major contributory factor in cancer development. Most bulk protein synthesis is initiated via recognition of the mRNA 5' cap and subsequent recognition of the initiator AUG codon by a directional scanning mechanism. However, several key regulators of tumour development are translated by a cap-independent pathway. Here we review eukaryotic translation initiation, its regulation and the ways in which this regulation can break down during tumorigenesis.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Components of the 48S translation pre-initiation complex. A polyadenylated mRNA (top) is circularised by being bound at its 5′ cap by eIF4E and at its 3′ end by poly(A)-binding protein (PABP). Both of these proteins are in turn bound to the scaffold protein eIF4G, which also provides a link to the 40S ribosomal subunit (bottom). For additional details see text.

References

    1. BerkelHJTurbat-HerreraEAShiRde BenedettiA2001Expression of the translation initiation factor eIF4E in the polyp- cancer sequence in the colon Cancer Epidemiol Biomarkers Prev 10663666 - PubMed
    1. BrassNHeckelDSahinUPfreundschuhMSybrechtGWMeeseE1997Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma Hum Mol Genet 63339 - PubMed
    1. CuestaRLaroiaGSchneiderRJ2000Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes Genes Dev 1414601470 - PMC - PubMed
    1. EberleJKrasagakisKOrfanosCE1997Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro Int J Cancer 71396401 - PubMed
    1. FredericksonRMMontineKSSonenbergN1991Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines Mol Cell Biol 1128962900 - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources