Semaphorins as signals for cell repulsion and invasion - PubMed (original) (raw)
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Semaphorins as signals for cell repulsion and invasion
Yoshio Goshima et al. J Clin Invest. 2002 Apr.
No abstract available
Figures
Figure 1
A phylogenic tree, showing the relationships between the vertebrate and invertebrate homologs of the CRMP, including the dihydropyrimidinase (DHPs) and UNC-33. Ce, C. elegans; Dm, Drosophila melanogaster.
Figure 2
Schematic representation of possible signal transduction pathways triggered by Sema3A. This semaphorin binds a complex containing the receptor proteins Plex-A1 and NP-1, as well as other, still poorly characterized signal transducing molecules. In neurons, some of the downstream events, including reorganization of the actin cytoskeleton and the consequent collapse of the axonal growth cone, are also influenced by pertussis toxin–sensitive (PTX-sensitive) G proteins. The CRMP appears to be central to several of the cellular responses to Sema3A.
Figure 3
Model of semaphorin functions in lung development. Sema3A opposes the effects of Sema3C and Sema3F, which activate branching morphogenesis in this tissue. The expression of the semaphorins and their receptors is tightly regulated, both spatially and temporally. The expression levels of semaphorins, neuropilins, and plexins are indicated as follows: ++, high; +, moderate; (see details in Kogashima et al, ref. 29).
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