Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases - PubMed (original) (raw)
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
Takashi Togo et al. J Neuroimmunol. 2002 Mar.
Abstract
We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease (AD), non-AD degenerative dementias and controls by semi-quantitative analysis of immunohistochemically stained tissue sections. In all cases, we found at least some T cells. The number of T cells was increased in the majority of AD cases compared with other cases. The phenotype of T cells in the AD brain indicates that they are activated but are not fully differentiated. Antigen-triggered clonal expansion is not likely to take place. Local inflammatory conditions might cause accumulation and activation of T cells in the AD brain.
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