Messenger RNA degradation: beginning at the end - PubMed (original) (raw)
Messenger RNA degradation: beginning at the end
Ambro van Hoof et al. Curr Biol. 2002.
Free article
Abstract
The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.
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