Dynamic multiphosphorylation passwords for activity-dependent gene expression - PubMed (original) (raw)
Review
. 2002 Apr 11;34(2):179-82.
doi: 10.1016/s0896-6273(02)00664-5.
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- PMID: 11970860
- DOI: 10.1016/s0896-6273(02)00664-5
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Review
Dynamic multiphosphorylation passwords for activity-dependent gene expression
Karl Deisseroth et al. Neuron. 2002.
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Abstract
Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mechanism (phosphorylating Ser133) while generating distinct patterns of gene expression? We review three Neuron articles that highlight novel ways Ca(2+) signals can trigger multiple phosphorylation events working in combination to control CREB and its interaction with coactivator molecules.
Comment on
- CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events.
Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. Kornhauser JM, et al. Neuron. 2002 Apr 11;34(2):221-33. doi: 10.1016/s0896-6273(02)00655-4. Neuron. 2002. PMID: 11970864 - Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.
Gau D, Lemberger T, von Gall C, Kretz O, Le Minh N, Gass P, Schmid W, Schibler U, Korf HW, Schütz G. Gau D, et al. Neuron. 2002 Apr 11;34(2):245-53. doi: 10.1016/s0896-6273(02)00656-6. Neuron. 2002. PMID: 11970866
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