Pathogenesis of colonic diverticula - PubMed (original) (raw)
Review
Pathogenesis of colonic diverticula
J Simpson et al. Br J Surg. 2002 May.
Abstract
Background: Diverticula are herniations through the colonic wall and are therefore likely to be due to a weakness within the wall, an alteration in intracolonic pressures or a combination of these factors. This article reviews these aspects in relation to the pathogenesis of colonic diverticula.
Methods: Medline and Science Citation Index searches were performed to locate English language articles relating to the pathogenesis of colonic diverticulosis published since 1960. Manual cross-referencing was also performed and some historical articles were included.
Results and conclusion: Several theories now exist about the development of colonic diverticula. The majority of the evidence suggests that the morphological changes are the response to a lifelong consumption of a low-residue diet. However, there are complex relations between colonic structure, motility and dietary factors, and it is likely that all of these (and possibly genetic influences) play a role in the pathogenesis to a greater or lesser degree.
Similar articles
- Origin of symptoms in diverticular disease.
Simpson J, Scholefield JH, Spiller RC. Simpson J, et al. Br J Surg. 2003 Aug;90(8):899-908. doi: 10.1002/bjs.4277. Br J Surg. 2003. PMID: 12905541 Review. - Segmentation and the localization of intraluminal pressure in the human colon, with special reference to the pathogenesis of colonic diverticula.
Painter NS, Truelove SC, Ardran GM, Tuckey M. Painter NS, et al. Gastroenterology. 1968 Apr;54(4):Suppl:778-80. Gastroenterology. 1968. PMID: 5653799 No abstract available. - Colonic diverticular disease: pathophysiology and clinical picture.
Parra-Blanco A. Parra-Blanco A. Digestion. 2006;73 Suppl 1:47-57. doi: 10.1159/000089779. Epub 2006 Feb 8. Digestion. 2006. PMID: 16498252 Review. - Pathogenesis of colonic diverticulitis and diverticulosis.
Sethbhakdi S. Sethbhakdi S. Postgrad Med. 1976 Dec;60(6):76-81. doi: 10.1080/00325481.1976.11708406. Postgrad Med. 1976. PMID: 792842 Review. - Colonic diverticula.
Eastwood M. Eastwood M. Proc Nutr Soc. 2003 Feb;62(1):31-6. doi: 10.1079/PNS2002233. Proc Nutr Soc. 2003. PMID: 12740054 Review.
Cited by
- Diverticular disease of the colon: new perspectives in symptom development and treatment.
Colecchia A, Sandri L, Capodicasa S, Vestito A, Mazzella G, Staniscia T, Roda E, Festi D. Colecchia A, et al. World J Gastroenterol. 2003 Jul;9(7):1385-9. doi: 10.3748/wjg.v9.i7.1385. World J Gastroenterol. 2003. PMID: 12854126 Free PMC article. Review. - Animal Models of Diverticulosis: Review and Recommendations.
Patel B, Guo X, Noblet J, Chambers S, Kassab GS. Patel B, et al. Dig Dis Sci. 2018 Jun;63(6):1409-1418. doi: 10.1007/s10620-018-5071-y. Epub 2018 Apr 20. Dig Dis Sci. 2018. PMID: 29679297 Review. - Recent advances in diverticular disease.
Simpson J. Simpson J. Curr Gastroenterol Rep. 2004 Oct;6(5):417-22. doi: 10.1007/s11894-004-0060-z. Curr Gastroenterol Rep. 2004. PMID: 15341720 Review. - Fiber and colorectal diseases: separating fact from fiction.
Tan KY, Seow-Choen F. Tan KY, et al. World J Gastroenterol. 2007 Aug 21;13(31):4161-7. doi: 10.3748/wjg.v13.i31.4161. World J Gastroenterol. 2007. PMID: 17696243 Free PMC article. Review. - Management of acute diverticulitis and its complications.
Welbourn HL, Hartley JE. Welbourn HL, et al. Indian J Surg. 2014 Dec;76(6):429-35. doi: 10.1007/s12262-014-1086-6. Epub 2014 May 23. Indian J Surg. 2014. PMID: 25614717 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical