Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain - PubMed (original) (raw)
Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain
M Jiang et al. Cytogenet Cell Genet. 2001.
Abstract
Rat PASS1 is a novel protein binding specifically to hsp27 and thus plays a role in regulating stress response in the living cell. Here we report on a human homologue of PASS1, encoded by the gene HSPBAP1. The gene was cloned and identified during a large-scale sequencing analysis of a human fetal brain cDNA library. The human protein shared 80% amino acid identity with rat PASS1. According to bioinformatics analysis, the HSPBAP1 gene is located on chromosome 3q21. RT-PCR analysis indicated that HSPBAP1 was abundant in thymus and pancreas but had a ubiquitously low expression pattern in other human adult tissues except for brain where it was absent.
Copyright 2002 S. Karger AG, Basel
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