Aging and survival of cutaneous microvasculature - PubMed (original) (raw)
Review
Aging and survival of cutaneous microvasculature
Edwin Chang et al. J Invest Dermatol. 2002 May.
Free article
Abstract
The growth and turnover of blood vessels in the skin is fundamental in normal development, wound repair, hair follicle cycling, tumor cell metastasis, and in many different states of cutaneous pathology. Whereas many investigations are focused on mechanisms of angiogenesis in the skin, the influence of cellular aging and replicative senescence (i.e., the inability, after a critical number of population doublings, to replicate) on microvascular remodeling events has received relatively less attention. In this article, we review the clinical and pathologic relationships associated with cutaneous vascular aging and update current knowledge of endothelial cell survival characteristics. A hypothesis is presented in which endothelial cell aging and survival are linked to molecular mechanisms controlling cell proliferation, quiescence, apoptosis, and cellular senescence. We review recent results demonstrating how activation of telomerase in human dermal microvascular endothelial cells affects their durability both in vitro and in vivo and conclude by linking these studies with current concepts involving endothelial cell precursors, control of postnatal somatic cell telomerase activity, and murine model systems.
Similar articles
- Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells.
Watanabe Y, Lee SW, Detmar M, Ajioka I, Dvorak HF. Watanabe Y, et al. Oncogene. 1997 May 1;14(17):2025-32. doi: 10.1038/sj.onc.1201033. Oncogene. 1997. PMID: 9160882 - Angiogenesis in wound healing and tumor metastasis.
Ruiter DJ, Schlingemann RO, Westphal JR, Denijn M, Rietveld FJ, De Waal RM. Ruiter DJ, et al. Behring Inst Mitt. 1993 Aug;(92):258-72. Behring Inst Mitt. 1993. PMID: 7504453 Review. - Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis.
Perruzzi CA, de Fougerolles AR, Koteliansky VE, Whelan MC, Westlin WF, Senger DR. Perruzzi CA, et al. J Invest Dermatol. 2003 Jun;120(6):1100-9. doi: 10.1046/j.1523-1747.2003.12236.x. J Invest Dermatol. 2003. PMID: 12787141 - Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix.
Li J, Zhang YP, Kirsner RS. Li J, et al. Microsc Res Tech. 2003 Jan 1;60(1):107-14. doi: 10.1002/jemt.10249. Microsc Res Tech. 2003. PMID: 12500267 Review. - Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome.
Stalmans I. Stalmans I. Verh K Acad Geneeskd Belg. 2005;67(4):229-76. Verh K Acad Geneeskd Belg. 2005. PMID: 16334858 Review.
Cited by
- Targeting SYK of monocyte-derived macrophages regulates liver fibrosis via crosstalking with Erk/Hif1α and remodeling liver inflammatory environment.
Chen X, Wang Z, Han S, Wang Z, Zhang Y, Li X, Xia N, Yu W, Jia C, Ni Y, Pu L. Chen X, et al. Cell Death Dis. 2021 Dec 1;12(12):1123. doi: 10.1038/s41419-021-04403-2. Cell Death Dis. 2021. PMID: 34853322 Free PMC article. - Optical coherence tomography angiography of normal skin and inflammatory dermatologic conditions.
Deegan AJ, Talebi-Liasi F, Song S, Li Y, Xu J, Men S, Shinohara MM, Flowers ME, Lee SJ, Wang RK. Deegan AJ, et al. Lasers Surg Med. 2018 Mar;50(3):183-193. doi: 10.1002/lsm.22788. Epub 2018 Jan 22. Lasers Surg Med. 2018. PMID: 29356051 Free PMC article. - The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice.
Zhao G, Cheng XW, Piao L, Hu L, Lei Y, Yang G, Inoue A, Ogasawara S, Wu H, Hao CN, Okumura K, Kuzuya M. Zhao G, et al. Aging Dis. 2017 May 2;8(3):287-300. doi: 10.14336/AD.2016.0920. eCollection 2017 May. Aging Dis. 2017. PMID: 28580185 Free PMC article. - The decay of stem cell nourishment at the niche.
Font de Mora J, Díez Juan A. Font de Mora J, et al. Rejuvenation Res. 2013 Dec;16(6):487-94. doi: 10.1089/rej.2013.1440. Rejuvenation Res. 2013. PMID: 23937078 Free PMC article. Review. - Aging and the pathogenic response to burn.
Rani M, Schwacha MG. Rani M, et al. Aging Dis. 2012 Apr;3(2):171-80. Epub 2011 Jul 4. Aging Dis. 2012. PMID: 22724078 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical