Genetic control of MHC class II expression - PubMed (original) (raw)
Review
. 2002 Apr:109 Suppl:S21-33.
doi: 10.1016/s0092-8674(02)00696-7.
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- PMID: 11983150
- DOI: 10.1016/s0092-8674(02)00696-7
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Review
Genetic control of MHC class II expression
Jenny Pan-Yun Ting et al. Cell. 2002 Apr.
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Abstract
The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression.
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